296242-37-0Relevant articles and documents
Asymmetric synthesis of (-)-tetrahydrolipstatin: an anti-aldol-based strategy.
Ghosh,Fidanze
, p. 2405 - 2407 (2007/10/03)
A stereoselective synthesis of (-)-tetrahydrolipstatin is described. The synthesis involves an asymmetric ester derived titanium enolate anti-aldol reaction, a nitro-aldol reaction to append the C-2' C(11) side chain, and a diastereoselective reduction of a beta-hydroxy ketone to an anti-1,3-diol functionality followed by its elaboration to (-)-tetrahydrolipstatin.