297162-49-3

Basic information

• Product Name: Azido-PEG6-CH2CO2t-butyl ester
• Synonyms: Azido-PEG6-CH2CO2t-butyl ester;N3-PEG6-CH2COOtBu
• CAS NO: 297162-49-3
• Molecular Formula: C₁₈H₃₅N₃O₈
• Molecular Weight: 421.4858
• Mol File: 297162-49-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Azido-PEG6-CH2CO2t-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Azido-PEG6-CH2CO2t-butyl ester(297162-49-3)
• EPA Substance Registry System: Azido-PEG6-CH2CO2t-butyl ester(297162-49-3)

Safety Data

• Hazardous Substances Data: 297162-49-3(Hazardous Substances Data)

Usage

Description

Azido-PEG6-CH2CO2t-butyl ester is a chemical compound that features an azide group and a t-butyl ester. The presence of a PEG (polyethylene glycol) spacer enhances the compound's solubility in aqueous media, making it more compatible with biological systems. The azide group is reactive and can participate in Click Chemistry reactions with alkyne, BCN, and DBCO, allowing for the formation of stable triazole linkages. Additionally, the t-butyl protected carboxyl group can be deprotected under acidic conditions, providing further functionalization options.

Uses

Used in Bioconjugation:
Azido-PEG6-CH2CO2t-butyl ester is used as a bioconjugation agent for the covalent attachment of biomolecules to various surfaces or other molecules. The expression is: Azido-PEG6-CH2CO2t-butyl ester is used as a bioconjugation agent for the covalent attachment of biomolecules to surfaces or other molecules due to its reactive azide group, which can participate in Click Chemistry reactions.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Azido-PEG6-CH2CO2t-butyl ester is used as a component in the development of drug delivery systems. The expression is: Azido-PEG6-CH2CO2t-butyl ester is used as a component in drug delivery systems for the solubility enhancement and functionalization of drug molecules, enabling targeted and controlled release of therapeutic agents.
Used in Material Science:
In the field of material science, Azido-PEG6-CH2CO2t-butyl ester is used as a building block for the synthesis of functional polymers and materials. The expression is: Azido-PEG6-CH2CO2t-butyl ester is used as a building block for the synthesis of functional polymers and materials, taking advantage of its reactive azide group and solubility-enhancing PEG spacer.
Used in Chemical Synthesis:
Azido-PEG6-CH2CO2t-butyl ester is used as an intermediate in chemical synthesis for the preparation of various complex molecules. The expression is: Azido-PEG6-CH2CO2t-butyl ester is used as an intermediate in chemical synthesis for the preparation of complex molecules, leveraging its reactivity and functional groups for further modification and synthesis.

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 86770-69-6 17-azido-3,6,9,12,15-pentaoxaheptadecan-1-ol 
• 2615-15-8 pentaethylene glycol 
• 28746-78-3 17-chloro-3,6,9,12,15-pentaoxaheptadecan-1-ol 
• 42749-28-0 toluene-4-sulfonic acid 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester 
• 297162-47-1 tert-butyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosanoate 
• 185990-09-4 tert-butyl 1-phenyl-2,5,8,11,14,17,20-heptaoxadocosan-22-oate 
• 24342-68-5 1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-ol 
• 89346-82-7 2-<2-<2-<2-(benzyloxy)ethoxy>ethoxy>ethoxy>ethyl 4-methylbenzenesulfonate 
• 86259-87-2 1-phenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 86520-52-7 2-[2-(2-azidoethoxy)ethoxy]ethanol 
• 352439-34-0 17-hydroxy-3,6,9,12,15-pentaoxaheptadec-1-yl methanesulfonate 
• 1530777-90-2 tert-butyl 20-(tosyloxy)-3,6,9,12,15,18-hexaoxicosanoate 

Downstream Products

• 1104083-46-6 20-amino-3,6,9,12,15,18-hexaoxaicosanoic acid 
• 1448451-74-8 C₂₁H₃₃N₃O₈ 
• 437655-96-4 20-(fluoren-9-ylmethyloxycarbonylamino)-3,6,9,12,15,18-hexaoxaeicosanoic acid 
• 297162-50-6 20-amino-3,6,9,12,15,18-hexaoxaeicosanoic acid tert-butyl ester 

Relevant articles and documents

Small and stable peptidic PEGylated quantum dots to target polyhistidine-tagged proteins with controlled stoichiometry

The use of the semiconductor quantum dots (QD) as biolabels for both ensemble and single-molecule tracking requires the development of simple and versatile methods to target individual proteins in a controlled manner, ideally in living cells. To address t

TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT

The present invention relates to a target protein degradation-inducing Degraducer, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases related to EED, EZH2, or PRC2 comprising same as an active ingredient. A novel compound represented by formula 1, according to the present invention is a Degraducer compound that induces degradation of a target protein, i.e., embryonic ectoderm development (EED) or polycomb repressive complex 2 (PRC2), utilizing cereblon E3 ubiquitin ligase, von Hippel-Lindau tumor suppressor (VHL) E3 ubiquitin ligase, mouse double minute 2 homolog (MDM2) E3 ubiquitin ligase, and cellular inhibitor of apoptosis protein 1 (cIAP) E3 ubiquitin ligase, wherein the compound has an aspect of remarkably achieving target protein degradation-inducing activity through a ubiquitin proteasome system (UPS), and therefore there is a useful effect in that it is possible to provide a pharmaceutical composition for preventing or treating diseases or conditions related to a target protein, and a functional health food composition for preventing or improving same, comprising said compound as an active ingredient.

Amide bond-containing monodisperse polyethylene glycols beyond 10000 da

Although monodisperse polyethylene glycols (M-PEGs) above 4000 Da are especially valuable in biomedical applications, their synthesis remains a long-standing challenge. To this end, a peptide-based strategy for such M-PEGs was developed. With macrocyclic sulfates as the key intermediates, a panel of oligoethylene glycol (OEG) containing ω-amino acids were prepared with high efficiency. Through solid phase peptide synthesis (SPPS), these amino acids were conveniently assembled into a series of amide bond-containing M-PEGs with high flexibility in molecular weight and amide density selection. With this strategy, an M-PEG of 10262 Da was prepared on a gram scale and its biocompatibility was assessed in a mice model.