297740-86-4Relevant articles and documents
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas
Daniele, Simona,La Pietra, Valeria,Barresi, Elisabetta,Di Maro, Salvatore,Da Pozzo, Eleonora,Robello, Marco,La Motta, Concettina,Cosconati, Sandro,Taliani, Sabrina,Marinelli, Luciana,Novellino, Ettore,Martini, Claudia,Da Settimo, Federico
, p. 4526 - 4538 (2016)
In glioblastoma multiforme (GBM), translocator protein (TSPO) and murine double minute (MDM)2/p53 complex represent two druggable targets. We recently reported the first dual binder 3 possessing a higher anticancer effect in GBM cells than the standards P
Solvent-free peptide synthesis assisted by microwave irradiation: Environmentally benign synthesis of bioactive peptides
Mahindra, Amit,Patel, Neha,Bagra, Nitin,Jain, Rahul
, p. 3065 - 3069 (2014/01/06)
An efficient and facile, solvent-free peptide synthesis assisted by microwave irradiation, using DIC/HONB as the coupling reagent combination is reported. Key features of this original protocol are solvent-free synthesis, very short reaction time and scal
Microwave-assisted solution phase peptide synthesis in neat water
Mahindra, Amit,Nooney, Karthik,Uraon, Shrikant,Sharma, Krishna K.,Jain, Rahul
, p. 16810 - 16816 (2013/09/23)
An environmentally benign protocol for solution phase peptide synthesis has been developed in neat water using TBTU/HOBt/DIEA as a coupling combination under microwave irradiation. Key features of this procedure are the replacement of commonly used toxic organic solvents like DMF and NMP, the use of lower amounts of reactants, compatibility with both N-α-Boc- and N-α-Fmoc-protected amino acids and all commonly used side-chain protective groups, short reaction time, and racemization-free synthesis in high yield and purity. The Royal Society of Chemistry 2013.
