2985-80-0

Basic information

• Product Name: Methanone, (4-chloro-2-hydroxyphenyl)phenyl-
• Synonyms: 4-chloro-2-hydroxybenzophenone;2-Hydroxy-4-chlor-benzophenon;4-Chlor-2-hydroxy-benzophenon;4-Chlor-2-hydroxybenzophenone;Methanone, (4-chloro-2-hydroxyphenyl)phenyl-
• CAS NO: 2985-80-0
• Molecular Formula: C13H9ClO2
• Molecular Weight: 232.666
• Mol File: 2985-80-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 77°C
• CAS DataBase Reference: Methanone, (4-chloro-2-hydroxyphenyl)phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-chloro-2-hydroxyphenyl)phenyl-(2985-80-0)
• EPA Substance Registry System: Methanone, (4-chloro-2-hydroxyphenyl)phenyl-(2985-80-0)

Safety Data

• Hazardous Substances Data: 2985-80-0(Hazardous Substances Data)

Usage

Preparation

Preparation by Fries rearrangement of m-chlorophenyl benzoate, ? with aluminium chloride, without solvent, at 140° for 1 h (54%), at 150° for 2 h (58%)], at 175° for 15 min (80%) or at 200° for 20 min; ? with titanium tetrachloride for 15 min at 175° (67%).

Upstream product

• 5607-64-7 4-chloro-2-anisoyl chloride 
• 71-43-2 benzene 
• 501-65-5 diphenyl acetylene 
• 1079392-32-7 C₁₄H₈ClNO₃ 
• 63503-60-6 3-chlorophenylboronic acid 
• 74993-54-7 O-(m-chloro-phenyl)-hydroxylamine 
• 591-50-4 iodobenzene 
• 93986-35-7 1-chloro-3-((3-phenylprop-2-yn-1-yl)oxy)benzene 
• 33302-52-2 1-chloro-3-(prop-2-yn-1-yloxy)benzene 
• 2005-08-5 4-chlorophenyl benzoate 
• 134-85-0 4-chlorobenzophenone 
• 108-43-0 3-monochlorophenol 
• 85-44-9 phthalic anhydride 
• 57479-70-6 2-methoxy-4-chlorobenzoic acid 

Downstream Products

• 78589-12-5 4-chloro-2-methoxybenzophenone 
• 1437756-83-6 7-chloro-4-phenyl-2H-chromen-2-one 
• 1461749-96-1 2-benzoyl-5-chlorophenyl benzoate 
• 1374987-95-7 4-(2-benzoyl-5-chlorophenoxy)but-2-enoic acid methyl ester 
• 875479-26-8 1-(2-methoxy-4-pyrrolidinophenyl)-1-phenylprop-2-yn-1-ol 
• 875479-22-4 2-methoxy-4-pyrrolidinobenzophenone 
• 108-43-0 3-monochlorophenol 
• 13189-55-4 3-chlorophenyl benzoate 

Relevant articles and documents

Water-Tolerant ortho-Acylation of Phenols

A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

Structural studies of a novel bioactive benzophenone derivative: (4-Chloro-2-hydroxy-phenyl)-phenyl-methanone

The title compound (4-Chloro-2-hydroxy-phenyl)-phenyl-methanone was synthesized and the product obtained was characterized by spectroscopic techniques, and finally the structure was confirmed by X-ray diffraction studies. The compound crystallizes in the orthorhombic crystal system with the space group Pbca with unit cell parameters, a = 14.0359(5) ?, b = 6.8084(3) ?, c = 23.1097(8) ?, and Z = 4. The structure exhibits an intramolecular hydrogen bond which closes an S(6) ring. No directional interactions beyond the van der Waals packing contacts were identified in the crystal structure.

Pd-catalyzed sp2 C-H hydroxylation with TFA/TFAA via weak coordinations

An efficient sp2 C-H hydroxylation has been developed for the synthesis of a wide range of functionalized phenols with aryl ketones, benzoates, benzamides, acetanilides and sulfonamides through palladium(II) catalysis. A trifluoroacetic acid (TFA)/trifluoroacetic anhydride (TFAA) co-solvent system serves as the oxygen source and is the critical factor for weak coordination promoted C-H activation. Georg Thieme Verlag Stuttgart New York.