300816-22-2 Usage
Description
4-CHLORO-6,7-DIHYDRO-5H-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDINE is a chemical compound belonging to the class of thieno[2,3-d]pyrimidines. It is characterized by its unique molecular structure, which features a cyclopentane ring fused with a thieno and pyrimidine ring system. The presence of a chlorine atom at the 4-position and a dihydro group at the 6,7-positions further distinguishes this compound.
Uses
Used in Pharmaceutical Industry:
4-CHLORO-6,7-DIHYDRO-5H-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDINE is used as a key intermediate in the synthesis of novel thieno[2,3-d]pyrimidines. These synthesized compounds exhibit significant antibacterial activity, making them valuable for the development of new antibiotics to combat drug-resistant bacterial infections.
Used in Chemical Research:
4-CHLORO-6,7-DIHYDRO-5H-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDINE serves as a versatile building block in the field of organic chemistry, particularly for researchers working on the design and synthesis of new molecules with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.
Used in Antibacterial Applications:
4-CHLORO-6,7-DIHYDRO-5H-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDINE is used as a precursor for the development of new antibacterial agents. The synthesized thieno[2,3-d]pyrimidines derived from this compound have demonstrated promising antibacterial properties, which can be further optimized and developed into effective treatments for bacterial infections.
Check Digit Verification of cas no
The CAS Registry Mumber 300816-22-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,0,8,1 and 6 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 300816-22:
(8*3)+(7*0)+(6*0)+(5*8)+(4*1)+(3*6)+(2*2)+(1*2)=92
92 % 10 = 2
So 300816-22-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H7ClN2S/c10-8-7-5-2-1-3-6(5)13-9(7)12-4-11-8/h4H,1-3H2
300816-22-2Relevant articles and documents
Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells
Yu, Meng,Zeng, Minghui,Pan, Zhaoping,Wu, Fengbo,Guo, Li,He, Gu
, (2020/02/03)
In this study, a series of thieno [2,3-d]pyrimidine derivatives were designed, synthesized and evaluated as novel AKT1 inhibitors. In vitro antitumor assay results showed that compounds 9d-g and 9i potently suppressed the enzymatic activities of AKT1 and
Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D2 receptor
Fyfe, Tim J.,Kellam, Barrie,Mistry, Shailesh N.,Scammells, Peter J.,Lane, J. Robert,Capuano, Ben
, p. 474 - 490 (2019/03/07)
We recently described a structurally novel series of negative allosteric modulators (NAMs) of the dopamine D2 receptor (D2R) based on thieno[2,3-d]pyrimidine 1, showing it can be structurally simplified to reveal low molecular weight, fragment-like NAMs that retain robust negative cooperativity, such as 3. Herein, we report the synthesis and functional profiling of analogues of 3, placing specific emphasis on examining secondary and tertiary amino substituents at the 4-position, combined with a range of substituents at the 5/6-positions (e.g. aromatic/aliphatic carbocycles). We identify analogues with diverse pharmacology at the D2R including NAMs with sub-μM affinity (9h) and, surprisingly, low efficacy partial agonists (9d and 9i).
Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors
El-Sharkawy, Lina Y.,El-Sakhawy, Rowaida A.,Abdel-Halim, Mohammad,Lee, Kevin,Piazza, Gary A.,Ducho, Christian,Hartmann, Rolf W.,Abadi, Ashraf H.
, (2018/04/20)
Novel cycloalkene-fused thienopyrimidine analogues with enhanced phosphodiesterase 5 (PDE5) inhibitory properties are presented. The structure of the reported scaffold was modulated through variation of the terminal cycloalkene ring size, as well as by va
