1321618-90-9

Basic information

• Product Name: N-(3-fluoro-4-(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
• Synonyms: N-(3-fluoro-4-(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
• CAS NO: 1321618-90-9
• Molecular Weight: 516.528
• Mol File: 1321618-90-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-fluoro-4-(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-fluoro-4-(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide(1321618-90-9)
• EPA Substance Registry System: N-(3-fluoro-4-(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide(1321618-90-9)

Safety Data

• Hazardous Substances Data: 1321618-90-9(Hazardous Substances Data)

Upstream product

• 868171-67-9 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid 
• 1335636-32-2 3-fluoro-4-(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yloxy)aniline 
• 300816-22-2 4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine 
• 399-96-2 4-amino-2-fluorophenol 

Relevant articles and documents

Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d] pyrimidine or furo[2,3-d]pyrimidine scaffold

A series of thieno[2,3-d]pyrimidines and furo[2,3-d]pyrimidines were synthesized and evaluated for the c-Met inhibition. Thieno[2,3-d]pyrimidine 6b stood out as the most potent showing an IC50 of 35.7 nM. This compound displayed high inhibitory effect on cell proliferation in BaF3-TPR-Met cells and showed high selectivity for c-Met family against other 14 tested kinases. However, compound 6b was found ineffective in the c-Met-dependent U-87MG human gliobastoma xenograft model that may be relevant to its poor PK profile.