868171-67-9

Basic information

• Product Name: 3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo-
• Synonyms: 3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo-
• CAS NO: 868171-67-9
• Molecular Formula: C₁₂H₈FNO₃
• Molecular Weight: 233.1952232
• Mol File: 868171-67-9.mol
• Article Data: 27

Chemical Properties

• Melting Point: 213-215 °C
• Boiling Point: 402.3 °C at 760 mmHg
• Flash Point: 197.1 °C
• Appearance: /
• Density: 1.655 g/cm³
• PKA: 2.07±0.20(Predicted)
• CAS DataBase Reference: 3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo-(868171-67-9)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo-(868171-67-9)

Safety Data

• Hazardous Substances Data: 868171-67-9(Hazardous Substances Data)

Usage

General Description

3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo- is a chemical compound with the molecular formula C12H9NO3F. It is a derivative of pyridinecarboxylic acid, and the presence of a fluorophenyl group makes it a potentially useful building block in the synthesis of pharmaceuticals and agrochemicals. 3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-2-oxo- has applications in the pharmaceutical industry due to its potential biological activities and therapeutic properties. It may also have uses in other industries, such as the production of dyes and pigments, as well as in research laboratories as a reagent for chemical analysis and organic synthesis. However, caution should be exercised when handling this compound, as it may have hazardous properties, and proper safety precautions should be followed.

Upstream product

• 609-71-2 1,2-dihydro-2-oxonicotinic acid 
• 10128-91-3 methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 
• 1765-93-1 4-fluoroboronic acid 
• 25991-27-9 methyl 2-oxo-2H-pyrane-3-carboxylate 
• 371-40-4 4-fluoroaniline 
• 10128-91-3 methyl 2-hydroxynicotinate 
• 28369-76-8 2-hydroxynicotinic acid chloride 
• 609-71-2 2-hydroxy-3-carboxypyridine 
• 868171-66-8 1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid methyl ester 

Downstream Products

• 1186376-04-4 1-(4-fluoro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid [4-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-amide 
• 1206801-40-2 N-(3-fluoro-4-(6-(2-methylmorpholino)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazol-5-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1234175-36-0 1-(4-fluoro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid [4-(6-oxo-5,6,7,8,9,10-hexahydro-benzo[c][1,8]naphthyridin-1-yloxy)-phenyl]-amide 
• 1345855-07-3 N-(4-(3-bromopyridin-4-yloxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1345855-08-4 N-(4-(3-(1-(cyanomethyl)-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1345855-06-2 N-(2,5-difluoro-4-(3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1345855-05-1 N-(2,5-difluoro-4-(5-(1-methyl-1H-pyrazol-4-yl)pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1345855-11-9 N-(4-(2-amino-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1428155-28-5 C₂₃H₁₄F₂N₆O₃ 
• 1428155-09-2 N-(3-fluoro-4-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1428155-22-9 N-(3-fluoro-4-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1428155-41-2 C₂₃H₁₅F₂N₇O₂ 
• 1428155-50-3 1-(4-fluorophenyl)-2-oxo-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)-1,2-dihydropyridine-3-carboxamide 
• 1428155-59-2 C₂₃H₁₅FN₆O₂ 

Relevant articles and documents

DERIVATIVES OF 2-OXO-N-(4-(PYRIMIDIN-4-YLOXY/THIO)PHENYL)-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE FOR USE AS PROTEIN KINASE INHIBITORS FOR THERAPY

2-oxo-N-(4-(pyrimidin-4-yloxy/thio)phenyl)-1,2-dihydropyridine-3-carboxamide derivatives are disclosed for use in the prevention and/or treatment of proliferative cell diseases and conditions including cancers. The compounds are considered to be capable of inhibiting cell proliferation and cause cancer cell apoptosis by inhibiting the activity of receptor tyrosine kinases (RTKs) such as TYRO3,AXL,MER and/or MET. The compounds have the general structure (I) shown below:

Aromatic ring dioxane quinazoline or quinoline compound, composition and application of aromatic ring dioxane quinazoline or quinoline compound

The invention relates to a novel compound serving as an inhibitor of kinase such as TRK, c-MET, AXL, MER and/or VEGFR2, a composition and application of the novel compound. Specifically, the inventionprovides a compound (as shown in formula (1)) or an isomer, a solvate, a hydrate, a pharmaceutically acceptable salt and a prodrug thereof, and a pharmaceutical composition containing the compound, wherein the compound has the activity of strongly inhibiting kinase such as TRK, c-MET, AXL, MER and/or VEGFR2. The invention further discloses application of the compound or the pharmaceutical composition in preparation of a medicine. The medicine is used for treating autoimmune diseases or cancers.

THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

A thienopyridine derivative compound represented by Formula 1 or pharmaceutically acceptable salts thereof have an excellent inhibitory effect on protein kinase activity, and accordingly, pharmaceutical compositions comprising same can be usefully used for the prevention or treatment of a disease associated with the activity of a protein kinase.