304-84-7 Usage
Description
ETHAMIVAN, also known as Vanillic acid diethylamide, is a pharmaceutical compound with various applications in the medical field. It is derived from vanillic acid and has been found to possess stimulant properties for the central nervous system and respiratory system. Its unique chemical structure allows it to interact with specific receptors in the body, making it a versatile compound for different therapeutic uses.
Uses
Used in Pharmaceutical Industry:
ETHAMIVAN is used as an antihypertensive agent for the treatment of high blood pressure. It helps in regulating blood pressure by constricting blood vessels, thus reducing the strain on the heart and blood vessels.
Used in Central Nervous System Stimulation:
ETHAMIVAN is used as a central nervous system stimulant to enhance cognitive function, alertness, and overall mental performance. Its stimulant properties make it a potential candidate for the treatment of conditions such as fatigue, depression, and attention deficit disorders.
Used in Respiratory System Stimulation:
ETHAMIVAN is used as a respiratory stimulant to improve breathing and oxygenation in patients with respiratory issues. It can be particularly useful in treating conditions like asthma, chronic obstructive pulmonary disease (COPD), and other respiratory disorders that require enhanced respiratory function.
Used in Emergency Medicine:
ETHAMIVAN, under the brand name Vandid by 3M Pharmaceuticals, is used in emergency medicine to counteract the effects of central nervous system and respiratory depression caused by various factors, such as drug overdose or severe illness. Its rapid-acting properties make it an essential component in the management of life-threatening situations.
Originator
Emivan,U.S.V.,US,1961
Manufacturing Process
4 g of vanillinic acid are mixed with 3.6 g of diethylamine, after cooling 2.2 g
of phosphorus pentoxide and the same amount of glass powder are added,
and then reacted with xylene until a thin paste has been formed. The latter is
boiled for some hours in the reflux cooler, moisture being excluded.
Decantation follows, and the residue is dissolved by means of a warm solution
of potassium carbonate until only glass powder or small amount of impurities
remain undissolved, and then the xylene solution is shaken up therewith, The
xylene solution is then separated, the aqueous layer is again extracted with
ether, and the ether extract is combined with the xylene solution. The mixture
is then distilled under the lowest possible pressure, collecting the fraction
between 170°C and 250°C (referred to 10 Torr), and purifying it by further
fractionation. In this way a slightly yellowish oil is obtained, which crystallizes
after some time. By dissolving in ligroin and crystallizing, pure vanillinic acid
diethylamide is obtained in the form of white needles; MP 95°C to 95.5°C.
Therapeutic Function
Central and respiratory stimulant
World Health Organization (WHO)
Etamivan is a central and respiratory stimulant.
Check Digit Verification of cas no
The CAS Registry Mumber 304-84-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,0 and 4 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 304-84:
(5*3)+(4*0)+(3*4)+(2*8)+(1*4)=47
47 % 10 = 7
So 304-84-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NO3/c1-4-13(5-2)12(15)9-6-7-10(14)11(8-9)16-3/h6-8,14H,4-5H2,1-3H3
