3057-63-4Relevant articles and documents
New system for peptide synthesis using N-acylpyrazoles
Kashima, Choji,Tsuruoka, Shiro,Mizuhara, Saori
, p. 413 - 424 (2007/10/03)
New system of peptide synthesis was described. The extension of one amino acid unit on the peptide chain was constituted from only 2 reaction steps, the conversion from esters to the corresponding N-acylpyrazoles and the subsequent aminolysis with amino esters. This new system was distinctive from the conventional peptide synthesis, which was consisted of 3 steps of the deprotection, the activation and the condensation. Moreover, the key intermediate N-acylpyrazoles exhibited the excellent properties of high sensitivity and separability for the chiral column on HPLC using the UV detector.