30611-16-6

Basic information

• Product Name: 2-(4-nitrophenyl)propionaldehyde
• Synonyms: 2-(4-nitrophenyl)propionaldehyde
• CAS NO: 30611-16-6
• Molecular Weight: 179.175
• Mol File: 30611-16-6.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 2-(4-nitrophenyl)propionaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitrophenyl)propionaldehyde(30611-16-6)
• EPA Substance Registry System: 2-(4-nitrophenyl)propionaldehyde(30611-16-6)

Safety Data

• Hazardous Substances Data: 30611-16-6(Hazardous Substances Data)

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 100-19-6 (4-nitrophenyl)ethanone 
• 75590-19-1 p-nitro-α-methylstyrene oxide 
• 109942-40-7 sodium 3-methyl-3-(4-nitrophenyl)oxirane-2-carboxylate 
• 100193-16-6 ethyl 3-methyl-3-(4-nitrophenyl)oxirane-2-carboxylate 
• 64-17-5 ethanol 
• 107-18-6 allyl alcohol 
• 100-13-0 4-nitrostyrene 
• 201230-82-2 carbon monoxide 
• 76346-07-1 (E)-4,4'-(but-1-ene-1,3-diyl)bis(nitrobenzene) 

Downstream Products

• 100-19-6 (4-nitrophenyl)ethanone 
• 1440418-53-0 (R)-di-tert-butyl 1-(2-(4-nitrophenyl)-1-oxo-propan-2-yl)hydrazine-1,2-dicarboxylate 
• 1417328-98-3 dimethyl (1-hydroxy-2-(4-nitrophenyl)propyl)phosphonate 
• 1417328-79-0 dimethyl ((1R,2R)-1-hydroxy-2-(4-nitrophenyl)propyl)phosphonate 
• 1296698-92-4 (S)-di-tert-butyl 1-(2-(4-nitrophenyl)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate 

Relevant articles and documents

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Synthesis of rac-ɑ-aryl propionaldehydes via branched-selective hydroformylation of terminal arylalkenes using water-soluble Rh-PNP catalyst

This work detailed the preparation of a class of water-soluble PNP ligands that differed by the nature of the substitute on phenyl ring of ligands. These ligands were incorporated into water-soluble rhodium-PNP complex catalysts that were used to regioselective hydroformylation of a series of terminal arylalkenes, providing efficient access to rac-α-aryl propionaldehydes in good to excellent yield (up to 97%) and branched-regioselectivity (up to 40:1 b/l ratio). Furthermore, gram-scale and diverse synthetic transformation demonstrated synthetic application of this methodology for non-steroidal antiinflammatory drugs.

Dual Catalysis Using Boronic Acid and Chiral Amine: Acyclic Quaternary Carbons via Enantioselective Alkylation of Branched Aldehydes with Allylic Alcohols

A ferrocenium boronic acid salt activates allylic alcohols to generate transient carbocations that react with in situ-generated chiral enamines from branched aldehydes. The optimized conditions afford the desired acyclic products embedding a methyl-aryl quaternary carbon center with up to 90% yield and 97:3 enantiomeric ratio, with only water as the byproduct. This noble-metal-free method complements alternative methods that are incompatible with carbon-halogen bonds and other sensitive functional groups.