3063-79-4

Basic information

• Product Name: 1-(4-METHYLPHENYL)-2-PYRROLIDINONE
• Synonyms: 1-(4-METHYLPHENYL)-2-PYRROLIDINONE;1-(4-METHYLPHENYL)-2-PYRROLIDINONE 99+%;1-(4-Methylphenyl)pyrrolidin-2-one;1-(p-Methylphenyl)pyrrolidine-2-one;2-pyrrolidinone, 1-(4-methylphenyl)-;1-(4-methylphenyl)-2-pyrrolidone;2-Pyrrolidinone, 1-p-tolyl-;1-(P-TOLYL)PYRROLIDIN-2-ONE
• CAS NO: 3063-79-4
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol File: 3063-79-4.mol
• Article Data: 36

Chemical Properties

• Melting Point: 86-88 °C
• Boiling Point: 306.53°C (rough estimate)
• Flash Point: 191 °C
• Appearance: Beige crystalline powder
• Density: 1.0582 (rough estimate)
• Vapor Pressure: 3.5E-06mmHg at 25°C
• Refractive Index: 1.5260 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.06±0.20(Predicted)
• CAS DataBase Reference: 1-(4-METHYLPHENYL)-2-PYRROLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHYLPHENYL)-2-PYRROLIDINONE(3063-79-4)
• EPA Substance Registry System: 1-(4-METHYLPHENYL)-2-PYRROLIDINONE(3063-79-4)

Safety Data

• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 3063-79-4(Hazardous Substances Data)

Usage

Chemical Properties

BEIGE CRYSTALLINE POWDER

InChI:InChI=1/C11H13NO/c1-9-4-6-10(7-5-9)12-8-2-3-11(12)13/h4-7H,2-3,8H2,1H3

Upstream product

• 96-48-0 4-butanolide 
• 106-49-0 p-toluidine 
• 616-45-5 2-pyrrolidinon 
• 624-31-7 4-tolyl iodide 
• 7108-41-0 cyclopropanecarboxylic acid p-tolylamide 
• 106-38-7 para-bromotoluene 
• 615-37-2 ortho-methylphenyl iodide 
• 1036030-62-2 [bis(1,10-phenanthroline)copper][bis(pyrrolidin-2-one)copper] 
• 356086-86-7 4-(p-tolylamino)butan-1-ol 
• 110-63-4 Butane-1,4-diol 
• 31053-03-9 N-(4-methylphenyl)piperidine 
• 2969-81-5 Ethyl 4-bromobutyrate 
• 54104-82-4 1-p-tolylpyrrolidine 
• 5720-05-8 4-methylphenylboronic acid 

Downstream Products

• 58973-35-6 N-(4-methylphenyl)pyrrolidine-2-thione 
• 162142-32-7 3-hydroxy-2-oxo-4-propionyl-1-(4-methylphenyl)-1,2,5,6-tetrahydropyridine 
• 6469-49-4 3-ethyl-1-(4-fluoro-phenyl)-6-p-tolyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one 
• 186667-93-6 diethyl [1-(4-methylphenyl)pyrrolidin-2-ylidene]malonate 
• 87962-88-7 4-p-toluidino-butyric acid 
• 6469-47-2 N-(4-methylphenyl)-6-aminohexan-3-one 

Relevant articles and documents

Synthetic method of N - aryl substituted lactam compound

The invention discloses a method. NSynthesis method of - aryl substituted lactam compound, and synthesis method thereof is promoted by tertiary butyl hydroperoxide and-tert-butyl hydroperoxideNMulti-step series reaction synthesis - aryl substituted saturated cyclic amine compoundN- Aryl substituted lactam compounds are simple and convenient to operate. The method has the advantages of no transition metal catalysis, wide substrate application range and the like, and is suitable for industrial production.

Ligand-Enabled Gold-Catalyzed C(sp2)-N Cross-Coupling Reactions of Aryl Iodides with Amines

The first example of ancillary (P,N)-ligand-enabled gold-catalyzed C-N cross-coupling reactions of aryl iodides with amines is reported. The high generality of the reaction in de novo synthesis, late-stage modifications, and cascade processes to access functionalized indolinones and carbazoles underscores the synthetic potential of the presented strategy. Monitoring the reaction with ESI-HRMS and NMR provided strong evidence for the in situ formation of putative high valent Au(III) intermediates.

PIFA-Promoted, Solvent-Controlled Selective Functionalization of C(sp2)-H or C(sp3)-H: Nitration via C-N Bond Cleavage of CH3NO2, Cyanation, or Oxygenation in Water

A novel nitration (via C(sp3)-N breaking/C(sp2)-N formation with CH3NO2) mediated by [bis(trifluoroacetoxy)iodo]benzene (PIFA) is described. The NO2 transfer from CH3NO2 to the aromatic group of the substrate is possible with careful selection of the solvent, NaX, and oxidant. In addition, the solvent-controlled C(sp2)-H functionalization can shift to an α-C(sp3)-H functionalization (cyanation or oxygenation) of the α-C(sp3)-H of cyclic amines.