306960-30-5

Basic information

• Product Name: 4-AMINOPYRIDO[2,3-D]PYRIMIDIN-5(8H)-ONE
• Synonyms: 4-AMINOPYRIDO[2,3-D]PYRIMIDIN-5(8H)-ONE;4-aminopyrido[2,3-d]pyrimidin-5(1H)-one
• CAS NO: 306960-30-5
• Molecular Formula: C₇H₆N₄O
• Molecular Weight: 162.15
• Mol File: 306960-30-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 300°
• Boiling Point: 300°C
• Appearance: /
• CAS DataBase Reference: 4-AMINOPYRIDO[2,3-D]PYRIMIDIN-5(8H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINOPYRIDO[2,3-D]PYRIMIDIN-5(8H)-ONE(306960-30-5)
• EPA Substance Registry System: 4-AMINOPYRIDO[2,3-D]PYRIMIDIN-5(8H)-ONE(306960-30-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 306960-30-5(Hazardous Substances Data)

Upstream product

• 3473-63-0 formamidine acetic acid 
• 7440-44-0 pyrographite 
• 98651-70-8 2-amino-4-methoxypyridine-3-carbonitrile 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 92277-14-0 O-acetylformamidoxime 
• 306960-29-2 2-amino-3-cyano-1H-pyrid-4-one 

Downstream Products

• 852222-48-1 4-amino-8-(4-amino-phenyl)-8H-pyrido[2,3-d]pyrimidin-5-one 
• 1426699-48-0 4-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]-2-bromo-6-chloro-3-ethoxybenzonitrile 
• 1426699-32-2 tert-butyl 3-{3-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]5-chloro-2-methoxy-6-methylphenyl}azetidine-1-carboxylate 
• 1426699-36-6 benzyl 3-{3-[1-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)ethyl]-5-chloro-2-ethoxy-6-methylphenyl}azetidine-1-carboxylate 
• 1426699-31-1 4-amino-8-[1-(3-bromo-5-chloro-2-methoxy-4-methylphenyl)ethyl]pyrido[2,3-d]pyrimidin-5(8h)-one 
• 1064135-71-2 4-amino-8-((2-(2-chlorophenyl)-8-methyl-quinolin-3-yl)methyl)pyrido[2,3-d]pyrimidin-5(8H)-one 
• 1064136-21-5 4-amino-8-((8-chloro-2-(2-chlorophenyl)-quinolin-3-yl)methyl)pyrido[2,3-d]pyrimidin-5(8H)-one 
• 1064136-18-0 4-amino-8-((5-chloro-3-(2-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)pyrido[2,3-d]pyrimidin-5(8H)-one 
• 852222-46-9 4-amino-8-(4-nitro-phenyl)-8H-pyrido[2,3-d]pyrimidin-5-one 
• 376393-88-3 C₃₀H₂₆N₄O₉ 
• 306960-35-0 C₂₈H₂₄N₄O₈ 
• 306960-37-2 8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-oxo-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one 
• 1053475-66-3 8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one 

Relevant articles and documents

Pyridopyrimidinones

The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and X′ have the designations cited in patent claim 1. Said c

PYRIDOPYRIMIDINONES

The invention relates to compounds of formula (I) wherein R1, R2 , R3 , R4 , R5, R6 , R7 , R8, R9, X and X' have the designations cited in patent claim 1. Said compounds are inhibitors of tyrosine kinases, especially TIE-2, and Raf kinases, and can, inter alia, be used for the treatment of tumours.

Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides

A purine nucleoside analog includes a pyrido[2,3-d]pyrimidine or a pyrimido[4,5-d]pyrimidine and further has a sugar moiety that is optionally modified at the C2′, C3′, C4′ and/or C5′ position. Particularly contemplated compounds also include prodrug forms of the purine nucleoside analogs, and both purine nucleoside analogs and the corresponding prodrugs are employed in the reduction of growth of neoplastic cells.