98651-70-8

Basic information

• Product Name: 2-amino-4-methoxypyridine-3-carbonitrile
• Synonyms: 2-amino-4-methoxypyridine-3-carbonitrile;3-Pyridinecarbonitrile,2-amino-4-methoxy-(9CI);2-Amino-3-cyano-4-methoxypyridine;2-Amino-4-methoxy-3-pyridinecarbonitrile;2-Amino-4-methoxypyridine-3-carbonitrile, 2-Amino-3-cyano-4-methoxypyridine
• CAS NO: 98651-70-8
• Molecular Formula: C₇H₇N₃O
• Molecular Weight: 149.14998
• Product Categories: PYRIDINE;NITRILE;Amines;blocks;Carboxes;Pyridines
• Mol File: 98651-70-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 211°
• Boiling Point: 352.7 °C at 760 mmHg
• Flash Point: 167.1 °C
• Appearance: /
• Density: 1.255 g/cm³
• Vapor Pressure: 3.76E-05mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: 2-8°C
• PKA: 4.07±0.47(Predicted)
• CAS DataBase Reference: 2-amino-4-methoxypyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-methoxypyridine-3-carbonitrile(98651-70-8)
• EPA Substance Registry System: 2-amino-4-methoxypyridine-3-carbonitrile(98651-70-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 98651-70-8(Hazardous Substances Data)

Usage

General Description

2-Amino-4-methoxypyridine-3-carbonitrile is a chemical compound with the molecular formula C7H8N4O. It is a pyridine derivative with a carbonitrile functional group and a methoxy and amino substituent. 2-amino-4-methoxypyridine-3-carbonitrile is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has been reported to have potential biological activities, such as antimicrobial and anticancer properties. Additionally, 2-amino-4-methoxypyridine-3-carbonitrile is a yellow to brown solid substance with a melting point of approximately 112-114°C. Overall, this chemical is important in the field of medicinal and agricultural chemistry due to its versatile reactivity and potential biological activity.

InChI:InChI=1/C7H7N3O/c1-11-6-2-3-10-7(9)5(6)4-8/h2-3H,1H3,(H2,9,10)

Upstream product

• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 95689-38-6 1,1-dicyano-4-(N,N-dimethylamino)-2-methoxy-1,3-butadiene 

Downstream Products

• 21642-98-8 4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 306960-29-2 2-amino-3-cyano-1H-pyrid-4-one 
• 852222-48-1 4-amino-8-(4-amino-phenyl)-8H-pyrido[2,3-d]pyrimidin-5-one 
• 852222-46-9 4-amino-8-(4-nitro-phenyl)-8H-pyrido[2,3-d]pyrimidin-5-one 
• 1152617-29-2 7-hydroxyimidazo[1,2-a]pyridine-8-carbonitrile 
• 1152617-02-1 7-hydroxy-3-phenylimidazo[1,2-a]pyridine-8-carbonitrile 
• 338412-35-4 N'-(3-cyano-4-methoxy-pyridin-2-yl)-N,N-dimethyl-formamidine 
• 306960-30-5 4-amino-5-oxo-pyrido[2,3-d]pyrimidine 
• 834869-04-4 7-Methoxy-imidazo[1,2-a]pyridine-8-carbonitrile 
• 306960-37-2 8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-oxo-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one 
• 1053475-66-3 8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one 
• 385435-85-8 C₄₁H₃₂N₄O₁₀ 
• 1053698-55-7 C₃₅H₂₆N₄O₈ 
• 1053257-01-4 C₃₆H₃₀N₄O₈ 

Relevant articles and documents

INDOLE AND BENZOXAZINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention relates to novel indole and benzoxazine derivatives which are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 ("mGluR2") and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.

SULFONAMIDES

The invention relates to compounds of formula (I) in which R6, R7, R8, R9 and X have the meanings cited in Claim 1. These compounds are inhibitors of tyrosinkinases, particularly TIE-2, and Raf kinases and can, among other things, be used for treating tumors.