30751-26-9Relevant articles and documents
Trypanosoma cruzi Malic Enzyme Is the Target for Sulfonamide Hits from the GSK Chagas Box
Bruder, Marjorie,Cordeiro, Artur T.,Do Nascimento Faria, Jessica,Eufrásio, Amanda G.,Fagundes, Michelle,Mercaldi, Gustavo F.,Mota, Sabrina G. R.,Ranzani, Americo T.
, p. 2455 - 2471 (2021/08/06)
Chagas disease, an infectious condition caused by Trypanosoma cruzi, lacks treatment with drugs with desired efficacy and safety profiles. To address this unmet medical need, a set of trypanocidal compounds were identified through a large multicenter phen