97-08-5 Usage
Description
4-Chloro-3-nitrobenzenesulfonyl chloride is an organic compound characterized by the presence of a chloro and nitro group attached to a benzene ring, with a sulfonyl chloride group attached to the benzene ring as well. 4-Chloro-3-nitrobenzenesulfonyl chloride is known for its reactivity and is commonly used as a synthetic intermediate in various chemical reactions.
Uses
Used in Pharmaceutical Industry:
4-Chloro-3-nitrobenzenesulfonyl chloride is used as a synthetic intermediate for the preparation of novel sulfonamide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones, which are known to increase melanin synthesis in murine B16 cells. This application is significant in the development of treatments for skin pigmentation disorders and other related conditions.
Used in Organic Synthesis:
In the field of organic synthesis, 4-chloro-3-nitrobenzenesulfonyl chloride serves as a key starting material for the preparation of functionalized 1H-indenes through copper-catalyzed arylative cyclization. This process is crucial for the synthesis of complex organic molecules with potential applications in various industries.
Used in Pesticide Development:
4-Chloro-3-nitrobenzenesulfonyl chloride is also utilized as a precursor in the synthesis of N-arylsulfonyl-3-acylindole arylcarbonyl hydrazone derivatives. These compounds have demonstrated potential nematicidal activity, making them valuable in the development of new pesticides for controlling nematode pests in agriculture.
Used in Cancer Research:
As a key component in the synthesis of sulfonamide analogs of ferrostatin-1 (fer-1), 4-chloro-3-nitrobenzenesulfonyl chloride contributes to the development of compounds with good ferroptosis inhibition properties. Ferroptosis is a form of regulated cell death, and its inhibition may have implications in cancer research and therapy.
Used in Chemical Synthesis:
In addition to its applications in pharmaceuticals and organic synthesis, 4-chloro-3-nitrobenzenesulfonyl chloride is also used in the synthesis of 4-chloro-3-nitrobenzene thiol, a compound that can be further utilized in various chemical reactions and processes.
Overall, 4-chloro-3-nitrobenzenesulfonyl chloride is a versatile compound with applications spanning across pharmaceuticals, organic synthesis, pesticide development, cancer research, and other chemical processes. Its reactivity and ability to serve as a synthetic intermediate make it a valuable component in the development of new compounds and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 97-08-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 7 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 97-08:
(4*9)+(3*7)+(2*0)+(1*8)=65
65 % 10 = 5
So 97-08-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H3Cl2NO4S/c7-5-2-1-4(14(8,12)13)3-6(5)9(10)11/h1-3H
97-08-5Relevant articles and documents
Amplified synthesis method of 3-nitro-4-halogeno-benzenesulfonamide
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Paragraph 0020, (2017/08/29)
An amplified synthesis method of 3-nitro-4-halogeno-benzenesulfonamide is disclosed. According to the method, 4-halogeno-benzenesulfonyl chloride which is used as a raw material undergoes nitration to prepare 3-nitro-4-halogeno-benzenesulfonyl chloride; and after aminolysis, 3-nitro-4-halogeno-benzenesulfonamide is prepared. By the synthesis method provided by the invention, the synthesis route by the adoption of chlorosulfonic acid is changed, and production safety is remarkably raised. The reaction condition is milder and is easy for production control. Thus, mass production of the compound is easier to implement and realize.
THROMBIN FUNCTION COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS BASED ON THEM
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Page/Page column 8, (2010/12/31)
This invention relates to new chemical compounds, application of these compound as thrombin inhibitors, and pharmaceutical compositions based on them, and can be used to treat and prevent thrombin-dependent thromboembolic events, and in research.
Tetrahydropyran derivatives
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Page 17, (2010/02/05)
A novel tetrahydropyran derivative which has an excellent apo B-related lipoprotein secretion-inhibiting activity of the following general formula (I) or a salt thereof: R8 and R9 are the same or different and each represents H, lower alkyl, R30-lower alkyl-, R31R32N-, optionally- substituted hetero ring, or R33R34R35C-; R8 and R9 may together form optionally-substituted hetero ring-; R30 represents optionally-substituted aryl, optionally-substituted hetero ring-, or lower alkyl-O-; R31 represents optionally-substituted aryl, or optionally-substituted hetero ring-; R33 represents HO-lower alkyl-, or optionally-substituted hetero ring-lower alkyl-; R34 represents optionally-substituted aryl-.
