873923-16-1Relevant articles and documents
Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors
Xiang, Jason S.,Hu, Yonghan,Rush, Thomas S.,Thomason, Jennifer R.,Ipek, Manus,Sum, Phaik-Eng,Abrous, Leila,Sabatini, Joshua J.,Georgiadis, Katy,Reifenberg, Erica,Majumdar, Manas,Morris, Elisabeth A.,Tam, Steve
, p. 311 - 316 (2007/10/03)
Aggrecanases are recently discovered enzymes that cleave aggrecan, a key component of cartilage. Aggrecanase inhibitors may provide a unique means to halt the progression of cartilage destruction in osteoarthritis. The synthesis and evaluation of biphenyl