307543-89-1

Basic information

• Product Name: 2-hydroxybenzaldehyde (5-acetyl-4-methyl-1,3-thiazol-2-yl)hydrazone
• Synonyms: 2-hydroxybenzaldehyde (5-acetyl-4-methyl-1,3-thiazol-2-yl)hydrazone
• CAS NO: 307543-89-1
• Molecular Formula: C13H13N3O2S
• Molecular Weight: 275.32622
• Mol File: 307543-89-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-hydroxybenzaldehyde (5-acetyl-4-methyl-1,3-thiazol-2-yl)hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxybenzaldehyde (5-acetyl-4-methyl-1,3-thiazol-2-yl)hydrazone(307543-89-1)
• EPA Substance Registry System: 2-hydroxybenzaldehyde (5-acetyl-4-methyl-1,3-thiazol-2-yl)hydrazone(307543-89-1)

Safety Data

• Hazardous Substances Data: 307543-89-1(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 5351-90-6 salicylaldehyde thiosemicarbazone 
• 1694-29-7 3-chloropentane-2,4-dione 
• 3043-28-5 3-bromopentane-2,4-dione 
• 79-19-6 thiosemicarbazide 
• 123-54-6 acetylacetone 

Relevant articles and documents

A zomethine-clubbed thiazoles as human tissue non-specific alkaline phosphatase (h -TNAP) and intestinal alkaline phosphatase (h -IAP) Inhibitors: kinetics and molecular docking studies

Abstract: Thiazole derivatives are known inhibitors of alkaline phosphatase, but various side effects have reduced their curative efficacy. Conversely, compounds bearing azomethine linkage display a broad spectrum of biological applications. Therefore, combining the two scaffolds in a single structural unit should result in joint beneficial effects of both. A new series of azomethine-clubbed thiazoles (3a–i) was synthesized and appraised for their inhibitory potential against human tissue non-specific alkaline phosphatase (h-TNAP) and human intestinal alkaline phosphatase (h-IAP). Compounds 3c and 3f were found to be most potent compounds toward h-TNAP with IC50 values of 0.15 ± 0.01 and 0.50 ± 0.01?μM, respectively, whereas 3a and 3f exhibited maximum potency for h-IAP with IC50 value of 2.59 ± 0.04 and 2.56 ± 0.02?μM, respectively. Molecular docking studies were also performed to find the type of binding interaction between potential inhibitor and active sites of enzymes. The enzymes inhibition kinetics studies were carried out to define the mechanism of enzyme inhibition. The current study leads to discovery of some potent inhibitors of alkaline phosphatase that is promising toward identification of compounds with druggable properties. Graphical abstract: [Figure not available: see fulltext.]

Design, synthesis, bioactivity, and DFT calculation of 2-thiazolyl-hydrazone derivatives as influenza neuraminidase inhibitors

Three series of thiazolylhydrazone derivatives were designed, synthesized, and evaluated for their neuraminidase (NA) inhibitory activity against influenza virus H1N1 in vitro. Compounds 1 and 2 were synthesized via the one-pot reaction and compound 3 was