31127-82-9 Usage
Description
Iodoxamic acid, also known as Endobil, Endomirabil, or Videocolangio, is a diagnostic aid primarily used as a radiopaque medium in medical imaging. It is a water-soluble, non-ionic contrast agent that enhances the visualization of internal body structures during radiographic procedures.
Uses
Used in Medical Imaging:
Iodoxamic acid is used as a radiopaque medium for enhancing the contrast in X-ray imaging, specifically in diagnostic procedures such as cholangiography, urography, and angiography. It allows for better visualization of the bile ducts, urinary tract, and blood vessels, respectively, by increasing their opacity to X-rays.
Used in Diagnostic Aids Industry:
In the diagnostic aids industry, iodoxamic acid is used as a contrast agent for improving the quality and accuracy of medical imaging. Its non-ionic nature and water solubility make it a preferred choice for various radiographic procedures, reducing the risk of adverse reactions and ensuring patient safety.
Originator
Endobil,Bracco
Manufacturing Process
148.5 g 4,7,10,13-tetraoxahexadecane-1,16-dinitrile (U.S. Patent No.
2,401,607) was added to a solution of 232 g (2.45 mol) concentrate sulfuric
acid in 290 ml absolute ethanol at 15°C. The mixture was heated at reflux for
15 hours, cooled and poured into 1000 g ice and 250 g ammonium sulfate. It
was extracted with methylene chloride, dried and a solvent was removed in
vacuum. The residue was distilled to give 4,7,10,13-tetraoxahexadecane-1,16-
dicarbonic acid dimethyl ester; BP: 190°-195°C/0.005 mm Hg.1 mol above prepared diester was saponificated with equivalent of NaOH in
water. The reaction mixture was heated for 90 minutes. On cooling it was
extracted with ether and the water layer was evaporated to dryness. The
residue was washed with acetone. The obtained disodium salt of 4,7,10,13-
tetraoxahexadecane-1,16-dicarbonic acid (yield 100%; MP: 102°-104°C) was
acidified with calculated quantity of HCl to give the dicarbonic acid. The
solvent was evaporated to dryness. Acetone was added to the residue for
removing a by-product (sodium chloride) by filtration. Acetone was evaporated
and the residue was extracted with ether, dried and evaporated. The residual
liquid was 4,7,10,13-tetraoxahexadecane-1,16-dicarbonic acid.100 ml thionyl chloride was cautious added to 56 g above prepared diacid and
heated at 40°-50°C and excess thionyl chloride was distilled in vacuum. The
residue was the 4,7,10,13-tetraoxahexadecane-1,16-dicarbonic acid
dichloride. The desired iodoxamic acid was prepared from above dichloride
and 3-amino-2,4,6-trijode benzoic acid, in dimethylacetamide
Therapeutic Function
Diagnostic aid
Check Digit Verification of cas no
The CAS Registry Mumber 31127-82-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,1,2 and 7 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 31127-82:
(7*3)+(6*1)+(5*1)+(4*2)+(3*7)+(2*8)+(1*2)=79
79 % 10 = 9
So 31127-82-9 is a valid CAS Registry Number.
InChI:InChI=1/C2H2INO2/c3-1(5)2(4)6/h(H2,4,6)
31127-82-9Relevant articles and documents
Radiopaque contrast media. XXIV. Synthesis and structure activity relationships of new hexaiodinated radiopaque compounds
Felder,Pitre,Fumagalli,Lorenzotti
, p. 912 - 924 (2007/10/06)
The synthesis of a series of new hexaiodinated radiopaque compounds is described. The relationship of structure to tolerability and biliary and urinary excretion was studied. Optimum tolerability was achieved with a compound which has been selected for further investigation as an angiographic contrast agent of the 'dimer' type. Iodoxamic acid showed a high biliary excretion combined with good tolerability, and is being developed as an injectable cholecystographic agent.
