31127-85-2 Usage
Description
alpha, oMega-Dipropionic acid triethylene glycol, also known as Bis-PEG4-acid, is a PEG linker that contains two terminal carboxylic acid groups. The hydrophilic PEG spacer enhances its solubility in aqueous media, while the terminal carboxylic acids can react with primary amine groups in the presence of activators, such as EDC or HATU, to form a stable amide bond.
Uses
Used in Pharmaceutical Industry:
alpha, oMega-Dipropionic acid triethylene glycol is used as a PEG linker for improving the solubility and stability of therapeutic molecules. The hydrophilic PEG spacer increases the aqueous solubility of the linked molecules, while the terminal carboxylic acids allow for the formation of stable amide bonds with primary amine groups, enhancing the overall stability and bioavailability of the drug.
Used in Drug Delivery Systems:
In the field of drug delivery, alpha, oMega-Dipropionic acid triethylene glycol is used as a versatile PEG linker to enhance the properties of drug carriers. The hydrophilic PEG spacer can improve the solubility and biocompatibility of drug carriers, such as nanoparticles or liposomes, while the terminal carboxylic acids enable covalent attachment of therapeutic molecules, ensuring their controlled release and targeted delivery to the desired site of action.
Used in Bioconjugation:
alpha, oMega-Dipropionic acid triethylene glycol is also used as a PEG-based bioconjugation agent for the attachment of various biomolecules, such as proteins, peptides, or antibodies, to other molecules or surfaces. The hydrophilic PEG spacer provides a flexible and hydrophilic environment for the biomolecule, while the terminal carboxylic acids facilitate the formation of stable amide bonds with primary amine groups on the target molecule or surface, enhancing the stability and bioactivity of the resulting bioconjugate.
Check Digit Verification of cas no
The CAS Registry Mumber 31127-85-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,1,2 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 31127-85:
(7*3)+(6*1)+(5*1)+(4*2)+(3*7)+(2*8)+(1*5)=82
82 % 10 = 2
So 31127-85-2 is a valid CAS Registry Number.
31127-85-2Relevant articles and documents
BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY
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Paragraph 0972; 0975; 0976, (2020/05/21)
The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Intramolecular End-to-End Reactions of Photoactive Terminal Groups Linked by Poly(oxyethylene) Chains
Ashikaga, Kazuo,Ito, Shinzaburo,Yamamoto, Masahide,Nishijima, Yasunori
, p. 2443 - 2450 (2007/10/02)
The triplet-sensitized photochemical reaction using a series of poly(oxyethylene) chains with a pair of photoactive terminal groups, dibenzazepine (DBA) chromophores (DBA-COCH2CH2(OCH2CH2)nOCH2CH2CO-DBA, n=0-10) was examined.The photoirradiation of bichromophoric compounds caused either intra- or intermolecular reactions.These reactions were kinetically analyzed by two different methods: the measurement of deactivation processes of the reaction intermediates (excited triplet state of DBA) by nanosecond laser photolysis and the quantitative analysis of the reaction products by GPC.The intramolecular deactivation rate constant, kintra, showed a remarkable chain-length dependence; the maximum kintra value appeared at n=5 and it was found to be 5.9X104 s-1.On the other hand, the intramolecular cyclization rate also depends on the chain length; the maximum quantum yield, φintrad, was given at n=7 (φintrad=0.51).The chain length for the maximum cyclization yield shifted slightly to the longer region than that for the maximum kintra value due to the restriction of the terminal structure (anti-configuration).The results obtained for this reaction system are compared with those obtained for the previously reported polymethylene system and the effect of chain flexibility on the intramolecular ring-closure reaction is discussed.
