312693-15-5 Usage
Description
2-Methoxybenzylzinc chloride is an organozinc compound that features a benzyl group with a methoxy substituent and a zinc chloride moiety. It is known for its reactivity and utility in various organic synthesis processes, making it a valuable chemical intermediate in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
2-Methoxybenzylzinc chloride is used as an intermediate in the preparation of 2,4-diamino-6-arylmethylquinazolines, which are potential dihydrofolate reductase (DHFR) inhibitors. DHFR inhibitors are important in the development of antimicrobial and anticancer drugs due to their ability to disrupt essential metabolic pathways in these disease-causing organisms.
Used in Organic Synthesis:
2-Methoxybenzylzinc chloride serves as a model organozinc compound in the Pd-catalyzed synthesis of α-aryl tertiary amides by reacting with carbamoyl chlorides. This reaction is significant in the synthesis of complex organic molecules and pharmaceutical agents, as it allows for the formation of carbon-carbon bonds and the introduction of aryl groups at the α-position of amides.
Used in Forensic Science:
In the field of forensic science, 2-Methoxybenzylzinc chloride is used as a substrate in the synthesis of forensically significant pyridine and pyrimidine derivatives. These compounds are of interest due to their presence in various illicit substances and their potential use as markers in forensic investigations. The synthesis of these derivatives using 2-Methoxybenzylzinc chloride aids in the development of analytical methods for their detection and identification.
Check Digit Verification of cas no
The CAS Registry Mumber 312693-15-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,2,6,9 and 3 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 312693-15:
(8*3)+(7*1)+(6*2)+(5*6)+(4*9)+(3*3)+(2*1)+(1*5)=125
125 % 10 = 5
So 312693-15-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H9O.ClH.Zn/c1-7-5-3-4-6-8(7)9-2;;/h3-6H,1H2,2H3;1H;/q-1;;+2/p-1/rC8H9O.ClZn/c1-7-5-3-4-6-8(7)9-2;1-2/h3-6H,1H2,2H3;/q-1;+1
312693-15-5Relevant articles and documents
Polyfunctional benzylic zinc chlorides by the direct insertion of magnesium into benzylic chlorides in the presence of LiCl and ZnCl2
Metzger, Albrecht,Piller, Fabian M.,Knochel, Paul
, p. 5824 - 5826 (2009/04/13)
Benzylic zinc chlorides bearing various functional groups are smoothly prepared by the direct insertion of magnesium into benzylic chlorides in the presence of LiCl and ZnCl2. The Royal Society of Chemistry.
