312904-12-4

Basic information

• Product Name: 1-Cyclohexene-1-carboxylic acid, 5-amino-3-(1-ethylpropoxy)-4-hydroxy-, ethyl ester, (3R,4S,5R)-
• CAS NO: 312904-12-4
• Molecular Formula: C14H25NO4
• Molecular Weight: 271.357
• Mol File: 312904-12-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Cyclohexene-1-carboxylic acid, 5-amino-3-(1-ethylpropoxy)-4-hydroxy-, ethyl ester, (3R,4S,5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclohexene-1-carboxylic acid, 5-amino-3-(1-ethylpropoxy)-4-hydroxy-, ethyl ester, (3R,4S,5R)-(312904-12-4)
• EPA Substance Registry System: 1-Cyclohexene-1-carboxylic acid, 5-amino-3-(1-ethylpropoxy)-4-hydroxy-, ethyl ester, (3R,4S,5R)-(312904-12-4)

Safety Data

• Hazardous Substances Data: 312904-12-4(Hazardous Substances Data)

Upstream product

• 312904-11-3 ethyl (3R,4S,5R)-5-N-allyllamino-3-(1-ethylpropoxy)-4-hydroxy-1-cyclohexene-1-carboxylate 
• 877238-95-4 (3aR,7R,7aS)-7-amino-2,2-diethyl-3a,6,7,7a-tetrahydro-benzo[1,3]dioxole-5-carboxylic acid ethyl ester 
• 204254-96-6 (1S,5R,6S)-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ethyl ester 
• 107-11-9 1-amino-2-propene 
• 1233402-45-3 C₁₄H₂₃NO₆ 
• 1233402-38-4 C₁₄H₂₄O₅ 
• 1233402-37-3 C₂₁H₃₄O₈ 
• 1233402-36-2 C₁₅H₂₆O₆ 
• 1233402-34-0 C₁₀H₁₈O₅ 
• 1233402-33-9 C₁₀H₁₆O₆ 
• 1257984-90-9 C₂₂H₃₆O₈ 
• 1257984-89-6 C₁₅H₂₆O₅ 
• 25636-49-1 3,3-dimethoxypentane 

Downstream Products

• 196618-13-0 oseltamivir 
• 312904-15-7 ethyl (3R,4R,5S)-5-N-allylamino-4-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate 
• 332047-18-4 ethyl (3R,4S,5R)-5-N-benzylideneamino-3-(1-ethylpropoxy)-4-methanesulfonyloxy-1-cyclohexene-1-carboxylate 
• 312904-18-0 ethyl (3R,4R,5S)-4-N-acetylamino-5-N-allylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate 
• 332047-17-3 ethyl (3R,4S,5R)-5-N-benzylideneamino-3-(1-ethylpropoxy)-4-hydroxy-1-cyclohexene-1-carboxylate 
• 877238-97-6 ethyl (3R,4S,5R)-3-(1-ethylpropoxy)-5-N-formylamino-4-methanesulfonyloxy-1-cyclohexene-1-carboxylate 
• 312904-17-9 ethyl (3R,4S,5R)-5-amino-3-(1-ethylpropoxy)-4-methanesulfonyloxy-1-cyclohexene-1-carboxylate 
• 332047-22-0 ethyl (3R,4S,5R)-5-N-formylamino-3-(1-ethylpropoxy)-4-hydroxy-1-cyclohexene-1-carboxylate 

Relevant articles and documents

Preparation method of oseltamivir

The invention discloses a preparation method of oseltamivir. The preparation method comprises the steps: taking (1S,5R,6S)-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ethyl ester as a raw material; carrying out a ring-opening reaction with benzylamine, carrying out catalytic hydrogenation debenzylation protection, carrying out Boc-protected N-acylation, carrying out an O-sulfonylation reaction with substituted sulfonyl chloride or trifluoromethanesulfonic anhydride, and carrying out a substitution reaction with benzylamine; carrying out catalytic hydrogenation debenzylation protection and O-acetylation reaction again; and finally removing Boc protection under an acidic condition to prepare oseltamivir. The preparation process is simple, low in cost and suitable for process amplification preparation to meet industrial production of oseltamivir raw drugs.

Process for the preparation of 4,5-diamino shikimic acid derivatives

The present invention relates to a process for the preparation of a 4,5-diamino shikimic acid derivative of formula and pharmaceutically acceptable addition salts thereof wherein R1, R1′ are independent of each other H or alkyl, R2 is an alkyl and R3, R4 are independent of each other H or an alkanoyl, with the proviso that not both R3 and R4 are H. 4,5-diamino shikimic acid derivatives of formula I, especially the (3R,4R,5S)-5-amino-4-acetylamino-3-(1-ethyl-propoxy)-cyclohex-1-ene-carboxylic acid ethyl ester and its pharmaceutically acceptable additional salts are potent inhibitors of viral neuraminidase.

Process for preparing 1,2-diamino compounds

The invention provides a multistep process for preparing 1,2-diamino compounds and pharmaceutically acceptable addition salts thereof from 1,2-epoxides.