31329-54-1 Usage
Description
Pregnanolone 3-β-D-Glucuronide is a glucuronide conjugate and metabolite derived from Pregnanolone (P711300). It is a biotransformation product that plays a significant role in the metabolism and regulation of the parent compound, Pregnanolone.
Uses
Used in Pharmaceutical Applications:
Pregnanolone 3-β-D-Glucuronide is used as an intermediate metabolite for the synthesis and development of pharmaceutical compounds. Its role in the metabolic pathway of Pregnanolone makes it a crucial component in the study and understanding of the bioavailability, efficacy, and safety of related drugs.
Used in Research and Development:
In the field of research and development, Pregnanolone 3-β-D-Glucuronide serves as a valuable compound for studying the metabolic processes and interactions of Pregnanolone. It can be utilized in the design and testing of new drugs targeting the same metabolic pathways, potentially leading to the development of novel therapeutic agents.
Used in Analytical Chemistry:
Pregnanolone 3-β-D-Glucuronide can be employed as a reference compound or standard in analytical chemistry for the identification, quantification, and quality control of Pregnanolone and its related metabolites in various biological samples, such as blood, urine, or tissue extracts.
Used in Drug Delivery Systems:
Similar to Gallotannin, Pregnanolone 3-β-D-Glucuronide may also be used in the development of drug delivery systems to improve the bioavailability and therapeutic outcomes of Pregnanolone and its derivatives. By incorporating this metabolite into novel drug delivery platforms, researchers can potentially enhance the efficacy and safety of related pharmaceutical compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 31329-54-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,3,2 and 9 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 31329-54:
(7*3)+(6*1)+(5*3)+(4*2)+(3*9)+(2*5)+(1*4)=91
91 % 10 = 1
So 31329-54-1 is a valid CAS Registry Number.
31329-54-1Relevant articles and documents
METABOLISM AND CONJUGATION OF PROGESTERONE BY BOVINE LIVER AND ADIPOSE TISSUES, IN VITRO
Clemens, J. D.,Estergreen, V. L.
, p. 287 - 306 (2007/10/02)
The ability of bovine liver and fat to metabolize progesterone and also to form glucuronide conjugates with these progestins in vitro was investigated.Tissue supernatants were incubated with progesterone, UDP-glucuronic acid, and a NADPH generating system for 5 hr, at 37 deg C.Steroids were identified by thin-layer chromatography, high performance liquid chromatography, and recrystallization to a constant specific activity.The total original radioactivity which could not be removed by exhaustive ether extraction (presumptive conjugates) was 44.7 +/- 14.2percent in liver, 5.0 +/- 3.6percent in subcutaneous fat, and 3.7 +/- 2.2percent in kidney fat samples.Progestins identified in liver samples include 5β-pregnane-3α,20α-diol (free and conjugate), 5β-pregnane-3α,20β-diol (free and conjugate), 3α-hydroxy-5β-pregnan-20-one (free and conjugate), 3β-hydroxy-5β-pregnan-20-one (free), 5β-pregnane-3,20-dione (free), and progesterone (conjugate).Progestins identified in both the free and conjugate fractions of subcutaneous fat and kidney fat samples include progesterone, 3α-hydroxy-5β-pregnan-20-one, 20β-hydroxy-4-pregnen-3-one, and 20α-hydroxy-4-pregnen-3-one.Differences due to sex of bovine used were noted.These results confirm the ability of bovine liver to readily metabolize progesterone and form glucuronide conjugates of these compounds and suggest that adipose tissues take an active role in these actions in cattle.
