3147-64-6 Usage
Description
6-Methoxysalicylic acid is a synthetic compound characterized by the presence of a methoxy group at the 6-position on the salicylic acid backbone. It possesses significant analgesic properties and has been utilized in various applications across different industries.
Uses
Used in Pharmaceutical Industry:
6-Methoxysalicylic acid is used as an internal standard for the determination of acetylsalicylic acid (aspirin, ASA) and its major metabolite, salicylic acid (SA), in animal plasma by LC/MS/MS. This application is crucial for ensuring accurate and reliable measurements in pharmacokinetic studies and therapeutic drug monitoring.
Used in Chemical Synthesis:
6-Methoxysalicylic acid is used as a dummy template molecule for the preparation of dummy molecularly imprinted polymers (DMIPs). These DMIPs are instrumental in the simultaneous selective removal and enrichment of ginkgolic acids (GAs) during the processing of Ginkgo biloba leaves, which is vital for the purification and standardization of Ginkgo biloba extracts in the herbal and dietary supplement industries.
Check Digit Verification of cas no
The CAS Registry Mumber 3147-64-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,1,4 and 7 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 3147-64:
(6*3)+(5*1)+(4*4)+(3*7)+(2*6)+(1*4)=76
76 % 10 = 6
So 3147-64-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H8O4/c1-12-6-4-2-3-5(9)7(6)8(10)11/h2-4,9H,1H3,(H,10,11)
3147-64-6Relevant articles and documents
Palladium-catalyzed ortho-C-H hydroxylation of benzoic acids
Luo, Feihua,He, Shuhua,Gou, Quan,Chen, Jinyang,Zhang, mingzhong
, (2021/10/06)
A simple Pd(OAc)2 catalyzed ortho-hydroxylation of benzoic acids using TBHP as the sole oxidant has been explored. This protocol features relatively broad substrate scope and operational simplicity. The compatibility of ortho-substituted substrates is an effective complement to the previous ortho-hydroxylation reaction.
Synthesis of the core structure of apicularen a by transannular cyclization.
Kuehnert, Sven M,Maier, Martin E
, p. 643 - 646 (2007/10/03)
[reaction: see text] An approach to the macrocyclic core of apicularen A is described. Thus, cross-coupling of the aryl triflate 7 with the vinylstannane 19 provided the styrene 20. Deprotection led to the dihydroxy acid 22. Through a size-selective macro
Synthesis of 3-methoxy 2-nitrobenzofuranes monomethoxylated on the homocycle. Effects against microorganisms
Lamotte,Demerseman,Royer,et al.
, p. 379 - 383 (2007/10/02)
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