31493-78-4

Basic information

• Product Name: 3-nitro-2-phenyl-benzo[b]thiophene
• Synonyms: 3-nitro-2-phenyl-benzo[b]thiophene
• CAS NO: 31493-78-4
• Molecular Weight: 255.297
• Mol File: 31493-78-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-nitro-2-phenyl-benzo[b]thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-nitro-2-phenyl-benzo[b]thiophene(31493-78-4)
• EPA Substance Registry System: 3-nitro-2-phenyl-benzo[b]thiophene(31493-78-4)

Safety Data

• Hazardous Substances Data: 31493-78-4(Hazardous Substances Data)

Upstream product

• 312612-67-2 1-(2-(methylthio)phenyl)-2-phenylacetylene 
• 143392-31-8 1-phenyl-2-ethyne 
• 1207-95-0 2-phenylbenzo[b]thiophene 
• 591-50-4 iodobenzene 
• 98437-23-1 benzo[b]thiophene-2-boronic acid 

Downstream Products

• 67447-50-1 3-amino-2-phenylbenzo(b)-thiophene 

Relevant articles and documents

K2S2O8-mediated radical cyclisation of 2-alkynylthioanisoles or -selenoanisoles: a green and regioselective route to 3-nitrobenzothiophenes and benzoselenophenes

An acid, transition-metal, and chromatography-free radical nitration/cyclisation of 2-alkynylthioanisoles or -selenoanisoles has been developed. This is the first example of the use of highly unstable 2-nitrovinyl radicals for C-S bond formation. This facile route efficiently produces 3-nitrobenzothiophenes and benzoselenophenes, which are difficult to accessviaclassical methods. Density functional theory (DFT) calculations were carried out to probe the reaction mechanism. The resulting products were tested for theirin vitroanti-tuberculosis activity, and compounds2dand2lshowed significant activities against sensitive and drug-resistant strains.