3160-38-1

Basic information

• Product Name: 4-(4-METHYLPHENYL)-3-BUTEN-2-ONE 97
• Synonyms: 4-(4-METHYLPHENYL)-3-BUTEN-2-ONE 97;1-(4-METHYLPHENYL)BUT-1-EN-3-ONE;4-(4-methylphenyl)but-3-en-2-one;1-(4-Methylphenyl)-1-butene-3-one;4-Methylstyrylmethyl ketone;Methyl 4-methylstyryl ketone;Methyl(4-methylstyryl) ketone;3-Buten-2-one, 4-(4-methylphenyl)-
• CAS NO: 3160-38-1
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 160.21
• Product Categories: C11 to C12;Carbonyl Compounds;Ketones
• Mol File: 3160-38-1.mol
• Article Data: 125

Chemical Properties

• Melting Point: 29-33 °C(lit.)
• Boiling Point: 280.6°Cat760mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 0.999g/cm³
• Vapor Pressure: 0.00375mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: 4-(4-METHYLPHENYL)-3-BUTEN-2-ONE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHYLPHENYL)-3-BUTEN-2-ONE 97(3160-38-1)
• EPA Substance Registry System: 4-(4-METHYLPHENYL)-3-BUTEN-2-ONE 97(3160-38-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 3160-38-1(Hazardous Substances Data)

Usage

Description

4-(4-METHYLPHENYL)-3-BUTEN-2-ONE 97, also known as 4-(p-Tolyl)-3-buten-2-one, is an organic compound that is involved in the Reformatsky reaction with ethyl α-bromopropionate to yield β-hydroxy esters. This chemical process is significant in the synthesis of various complex molecules and has potential applications in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
4-(4-METHYLPHENYL)-3-BUTEN-2-ONE 97 is used as a key intermediate in the synthesis of pharmaceutical compounds. Its involvement in the Reformatsky reaction allows for the creation of β-hydroxy esters, which are essential building blocks for various drug molecules. This application is crucial for the development of new medications and the improvement of existing ones.
Used in Chemical Industry:
In the chemical industry, 4-(4-METHYLPHENYL)-3-BUTEN-2-ONE 97 is utilized as a reactant in the Reformatsky reaction to produce β-hydroxy esters. These esters can be further transformed into other valuable chemicals, contributing to the synthesis of a wide range of products, including specialty chemicals, polymers, and additives.
Overall, 4-(4-METHYLPHENYL)-3-BUTEN-2-ONE 97 plays a vital role in both the pharmaceutical and chemical industries due to its ability to participate in the Reformatsky reaction and contribute to the synthesis of essential compounds and materials.

InChI:InChI=1/C11H12O/c1-9-3-6-11(7-4-9)8-5-10(2)12/h3-8H,1-2H3/b8-5+

Upstream product

• 33604-67-0 (4-methylphenyl)azo 4-methylphenyl sulfone 
• 78-94-4 methyl vinyl ketone 
• 624-31-7 4-tolyl iodide 
• 104-87-0 4-methyl-benzaldehyde 
• 67-64-1 acetone 
• 7774-79-0 4-(4-methylphenyl)butan-2-one 
• 909413-26-9 6-(tert-butyl)-12-(p-tolyl)-5,6,7,12-tetrahydrodibenzo[c,f][1,5]azastibocine 
• 32271-53-7 (E)-4-(p-tolyl)but-3-en-2-ol 
• 13277-99-1 4-methylbenzaldehyde-α-d₁ 
• 108-24-7 acetic anhydride 
• 73839-45-9 (E)-trimethyl[2-(4-methylphenyl)ethenyl]silane 
• 135689-01-9 4-hydroxy-4-(4-methylphenyl)-butan-2-one 
• 24165-63-7 1-p-tolyl-3-buten-1-ol 
• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 

Downstream Products

• 1420293-48-6 4-((4-chlorophenyl)thio)-4-(p-tolyl)butan-2-one 
• 1383844-39-0 C₂₂H₂₇NO₂ 
• 1372687-86-9 5-methyl-5-(3-oxo-1-p-tolylbutyl)-3-phenyl-2-thioxothiazolidin-4-one 
• 1371579-01-9 (1E,4E)-1-(4-nitrophenyl)-5-p-tolylpenta-1,4-dien-3-one 
• 1371579-17-7 (1E,4E)-1-(3-nitrophenyl)-5-p-tolylpenta-1,4-dien-3-one 
• 1371579-45-1 2-bromo-N-(3-((1E,4E)-3-oxo-5-p-tolylpenta-1,4-dienyl)phenyl)acrylamide 
• 1371579-29-1 2-bromo-N-(4-((1E,4E)-3-oxo-5-p-tolylpenta-1,4-dienyl)phenyl)acrylamide 
• 1373490-24-4 1-(hepta-1,5-dien-4-yl)-4-methylbenzene 
• 1373490-23-3 (E)-1-methyl-4-(3-methylhexa-1,5-dien-1-yl)benzene 
• 1373490-27-7 (E)-2-methyl-5-(4-(p-tolyl)but-3-en-2-yl)thiophene 
• 1372611-02-3 1-hydroxy-8-methoxy-3-p-tolyl-6H-benzo[c]chromen-6-one 
• 1372610-97-3 1-hydroxy-3-p-tolyl-6H-benzo[c]chromen-6-one 
• 1353042-40-6 (E)-ethyl 2-hydroxy-4-oxo-6-(p-tolyl)hex-5-enoate 
• 1350624-27-9 (E)-2-oxo-4-(p-tolyl)but-3-en-1-yl formate 

Relevant articles and documents

Enantioselective one-pot two-step synthesis of hydrophobic allylic alcohols in aqueous medium through the combination of a Wittig reaction and an enzymatic ketone reduction

A one-pot two-step process for the enantioselective synthesis of hydrophobic allylic alcohols was developed, which comprises ketone formation by the Wittig reaction and their enzymatic in situ biotransformation into the desired target products. By means of this combined Wittig reaction and bioreduction, the allylic alcohols were prepared with conversions of up to 90 %, and with excellent enantioselectivities of >99 % ee. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Green sustainable approach for carbon–carbon bond-forming reactions using FeNPs/DETA@rGO nano-catalyst

We have fabricated eccentric highly persuasive bifunctional FeNPs/DETA@rGO (where DETA = diethylenetriamine) nano-catalyst with a dual activation mechanism by presenting aliphatic amine on the basal and/or edges sites offering a base characteristic and Fe

Silica Jar-with-Lid as Chemo-Enzymatic Nano-Compartment for Enantioselective Synthesis inside Living Cells

Nanodevices, harvesting the power of synthetic catalysts and enzymes to perform enantioselective synthesis inside cell, have never been reported. Here, we synthesized round bottom jar-like silica nanostructures (SiJARs) with a chemo-responsive metal-silic