31601-68-0

Basic information

• Product Name: 4-(2,5-DIOXO-PYRROLIDIN-1-YL)-BUTYRIC ACID
• Synonyms: ASINEX-REAG BAS 09538591;4-(2,5-DIOXOPYRROLIDIN-1-YL)BUTANOIC ACID;4-(2,5-DIOXO-PYRROLIDIN-1-YL)-BUTYRIC ACID;ART-CHEM-BB B030210;OTAVA-BB 1113767;UKRORGSYN-BB BBV-035454;VITAS-BB TBB002226;2,5-Dioxo-1-Pyrrolidinebutanoicacid
• CAS NO: 31601-68-0
• Molecular Formula: C₈H₁₁NO₄
• Molecular Weight: 185.18
• Mol File: 31601-68-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 441.1°Cat760mmHg
• Flash Point: 220.6°C
• Appearance: /
• Density: 1.342g/cm³
• Vapor Pressure: 5.16E-09mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: 4-(2,5-DIOXO-PYRROLIDIN-1-YL)-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,5-DIOXO-PYRROLIDIN-1-YL)-BUTYRIC ACID(31601-68-0)
• EPA Substance Registry System: 4-(2,5-DIOXO-PYRROLIDIN-1-YL)-BUTYRIC ACID(31601-68-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 31601-68-0(Hazardous Substances Data)

Usage

General Description

4-(2,5-DIOXO-PYRROLIDIN-1-YL)-BUTYRIC ACID, also known as N-Acetyl-Glutamine or N-Acetyl-L-Glutamine, is an organic compound and a derivative of the amino acid glutamine. It is commonly used in the field of pharmaceuticals, mainly as a potential prodrug of glutamine for the treatment of bodily disorders such as cancer, intestinal inflammation, and immune system dysfunctions. This chemical has shown to possess anti-inflammatory and immunomodulatory properties, making it a potential candidate for therapeutic use in the future. Additionally, it has also been studied for its potential in improving cognitive function and mental health due to its role in the synthesis of neurotransmitters in the brain.

InChI:InChI=1/C8H11NO4/c10-6-3-4-7(11)9(6)5-1-2-8(12)13/h1-5H2,(H,12,13)

Upstream product

• 108-30-5 succinic acid anhydride 
• 56-12-2 4-amino-n-butyric acid 
• 2740-00-3 indolizidin-3-one 
• 616-45-5 2-pyrrolidinon 

Downstream Products

• 1207598-10-4 N-(2-(5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)-1H-indol-1-yl)ethyl)-4-(2,5-dioxopyrrolidin-1-yl)butanamide 
• 1207598-11-5 N-(2-(5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)-1H-indol-1-yl)ethyl)-4-(2,5-dioxopyrrolidin-1-yl)butanamide 

Relevant articles and documents

Amide compounds for regulating WNT signal channel and application of compounds

The invention belongs to the technical field of medicine, and particularly relates to amide compounds for regulating a WNT signal channel and an application of the compounds. The compounds have a structure represented by a general formula I shown in the description.

Ruthenium Tetroxide Oxidation of 1-Azabicycloalkan-2-ones

The ruthenium tetroxide (RuO4) oxidation of 1-azabicycloalkan-2-ones was investigated.The oxidation of quinolizidin-4-one (4), indolizidin-3-one (9), pyrrolizidin-3-one (11) and tetrahydro-1H,3H-pyrrolooxazol-3-one (12) occured at the bridgehead tertiary carbon atom and afforded the corresponding hydroxy compounds (from 11 and 12) or the imidobutyric acid derivatives (from 4 and 9).This regioselectivity is contrary to the general situation in the oxidation of N-acyl cyclic amines.Howewer, 1-azabicyclooctan-8-one (17) was oxidized at the secondary carbon atom to give the 2,8-dione (18).Keywords: oxidation; ruthenium tetroxide oxidation; hydroxylation; regioselectivity; 1-azabicycloalkan-2-one; ruthenium tetroxide; two-phase method