31788-88-2 Usage
General Description
(2-AMINO-2-PHENYLETHYL)DIMETHYLAMINE is a chemical compound with the formula C10H15N. It is an organic amine, specifically a secondary amine, which consists of a dimethylamine moiety substituted by a 2-phenylethyl group. It is used in various industrial and pharmaceutical applications, including as a building block for the synthesis of other compounds. This chemical is an important intermediate in the production of pharmaceuticals and agrochemicals. Additionally, it is also used in research and development for potential new applications.
Check Digit Verification of cas no
The CAS Registry Mumber 31788-88-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,7,8 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 31788-88:
(7*3)+(6*1)+(5*7)+(4*8)+(3*8)+(2*8)+(1*8)=142
142 % 10 = 2
So 31788-88-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H16N2/c1-12(2)8-10(11)9-6-4-3-5-7-9/h3-7,10H,8,11H2,1-2H3/p+2/t10-/m0/s1
31788-88-2Relevant articles and documents
α-Methylation at benzylic fragment of N-aryl-N′-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model
Gomtsyan, Arthur,Bayburt, Erol K.,Keddy, Ryan,Turner, Sean C.,Jinkerson, Tammie K.,Didomenico, Stanley,Perner, Richard J.,Koenig, John R.,Drizin, Irene,McDonald, Heath A.,Surowy, Carol S.,Honore, Prisca,Mikusa, Joe,Marsh, Kennan C.,Wetter, Jill M.,Faltynek, Connie R.,Lee, Chih-Hung
, p. 3894 - 3899 (2008/02/09)
SAR studies for N-aryl-N′-benzyl urea class of TRPV1 antagonists have been extended to cover α-benzyl alkylation. Alkylated compounds showed weaker in vitro potencies in blocking capsaicin activation of TRPV1 receptor, but possessed improved pharmacokinetic properties. Further structural manipulations that included replacement of isoquinoline core with indazole and isolation of single enantiomer led to TRPV1 antagonists like (R)-16a with superior pharmacokinetic properties and greater potency in animal model of inflammatory pain.