3181-38-2Relevant articles and documents
Synthesis of isotopically labelled versions of adenosine agonist GR79236
Wadsworth, Alan H.,Newman, John J.,Wipperman, Mark D.,Fellows, Ian,Sutherland, Derek R.
, p. 11 - 28 (2000)
Versions of adenosine receptor agonist GR79236, labelled either with carbon-14 at C-8 of the purine ring or with tritium in the cyclopentyl ring, were prepared in overall yields of 64% and 25% respectively. A mass labelled [M + 4] version containing carbon-13, nitrogen-15, and deuterium was also prepared in 3% yield.
SAICAR Synthesis method
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Paragraph 0053-0056; 0076-0078; 0098-0100, (2021/11/06)
A method of synthesizing SAICAR of the present invention is carried out at 5 - amino -1 - ((). 2R. 3R. 4S. 5R-3, 4 -dihydroxy -5 - (hydroxymethyl) tetrahydrofuran -2 -yl) -1H- Imidazol -4 - formamide is the starting material and is sequentially subjected to 5 - amino -1 - ((). 3aR. 4R. 6R. 6aR) -6 - (Hydroxymethyl) -2, 2 -dimethyltetrahydrofuran [3,4 -]d] [1, 3] Diox -4 - group) -1H-imidazole -4 -carboxamide. 5 - Amino -1 - (()3aR. 4R. 6R. 6aR) -6 - (Hydroxymethyl) -2, 2 -dimethyltetrahydrofuran [3,4 -]d] [1, 3] Diox -4 - group) -1H- Imidazole -4 - carboxylic acid, dibenzyl (5 - amino -1 -) (()3aR. 4R. 6R. 6aR) -6 - (Hydroxymethyl) -2, 2 -dimethyltetrahydrofuran [3,4 -]d] [1, 3] Diox -4 - group) -1H- Imidazol -4 - carbonyl) . LOf - aspartic acid and the like to obtain a finished product purity of up to 99.6%, impurities 0.4%, diastereomeric excess (de) values 97.3% and a yield 16.9%.
A process for preparing natural nucleoside powder clitocybin method
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Paragraph 0021; 0025-0027, (2017/10/26)
The invention discloses a new method for preparing natural nucleoside nebularine. According to the method disclosed by the invention, cheap inosine is used as a raw material and is subjected to three reactions including acyl protection, sulfuration and desulfuration to finally obtain the target product nebularine; in the desulfuration step, since 50% nitric acid is used as a desulfuration agent, such reaction conditions easily causing explosion as diazotization in the conventional synthesis method can be avoided, no heavy metal catalyst is used, no column chromatography is needed in the whole process, large-scale synthesis can be realized easily; and moreover, the new method for preparing natural nucleoside nebularine is suitable for research on medicine activity and further large-scale preparation.
Selective Acylation of Nucleosides, Nucleotides, and Glycerol-3-phosphocholine in Water
Fernández-García, Christian,Powner, Matthew W.
supporting information, p. 78 - 83 (2016/12/26)
A convenient selective synthesis of 2′,3′-di-O-acetyl-nucleotide-5′-phosphates, 2′,3′-di-O-acetyl-nucleotide-5′-triphosphates and 2′,3′,5′-tri-O-acetyl-nucleosides in water has been developed. Furthermore, a long-chain selective glycerol-3-phosphocholine diacylation is elucidated. These reactions are environmentally benign, rapid, high yielding, and the products are readily purified. Importantly, this reaction may indicate a prebiotically plausible reaction pathway for the selective acylation of key metabolites to facilitate their incorporation into protometabolism.