320778-92-5 Usage
Description
1,2-Cyclohexanediamine,N,N-dimethyl-,(1R,2R)-(9CI), also known as (1R,2R)-2-N,2-N-dimethylcyclohexane-1,2-diamine, is a chiral amine catalyst that is characterized as a colorless liquid. It plays a significant role in various chemical reactions due to its unique structure and properties.
Uses
Used in Chemical Synthesis:
1,2-Cyclohexanediamine,N,N-dimethyl-,(1R,2R)-(9CI) is used as a chiral amine catalyst for asymmetric direct aldol and Michael addition reactions. Its application in these reactions is crucial for the synthesis of complex organic molecules with high enantioselectivity and yield, which is essential in the pharmaceutical and fine chemicals industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1,2-Cyclohexanediamine,N,N-dimethyl-,(1R,2R)-(9CI) is used as a key intermediate in the synthesis of various drugs and drug candidates. Its ability to act as a chiral amine catalyst allows for the production of enantiomerically pure compounds, which is vital for the development of effective and safe medications.
Used in Fine Chemicals Industry:
1,2-Cyclohexanediamine,N,N-dimethyl-,(1R,2R)-(9CI) is also utilized in the fine chemicals industry for the production of specialty chemicals, fragrances, and flavors. The chiral nature of this compound enables the creation of high-quality enantiomerically pure products, which are in high demand for various applications.
Used in Research and Development:
In the field of research and development, 1,2-Cyclohexanediamine,N,N-dimethyl-,(1R,2R)-(9CI) serves as an important tool for studying the mechanisms of asymmetric catalysis and the development of new synthetic methods. Its unique properties make it a valuable asset in advancing the understanding of chemical reactions and the design of novel catalysts.
Check Digit Verification of cas no
The CAS Registry Mumber 320778-92-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,0,7,7 and 8 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 320778-92:
(8*3)+(7*2)+(6*0)+(5*7)+(4*7)+(3*8)+(2*9)+(1*2)=145
145 % 10 = 5
So 320778-92-5 is a valid CAS Registry Number.
320778-92-5Relevant articles and documents
Synthesis, resolution, and absolute configuration of trans-1-amino-2-dimethylaminocyclohexane
Christoffers, Jens,Schulze, Yvonne,Pickardt, Joachim
, p. 1765 - 1769 (2001)
Racemic trans-1-amino-2-dimethylaminocyclohexane was prepared by aziridine ring opening reaction of 7-azabicyclo[4.1.0]heptane with HNMe2. The resolution of the racemate was accomplished by crystallization as the L-tartrate. The optical purity
The first catalytic, enantioselective aza-Henry reaction of an unactivated cyclic imine
Amarasinghe, Nilupa R.,Todd, Matthew H.,Turner, Peter
supporting information, p. 2954 - 2958,5 (2020/10/15)
The aza-Henry reaction is an efficient route to important chiral, vicinal diamines. Reports of the asymmetric version typically use electron-deficient acyclic imines. We report the first example of a catalytic, asymmetric aza-Henry reaction on an unfunctionalized cyclic imine that gives access to enantiopure diamine derivatives under experimentally straightforward conditions. The stereocentre is established through the initial nitromethane addition to the imine. The scalemic intermediate may be trapped through acylation, then crystallized. Copyright
A simple primary-tertiary diamine-Bronsted acid catalyst for asymmetric direct aldol reactions of linear aliphatic ketones
Luo, Sanzhong,Xu, Hui,Li, Jiuyuan,Zhang, Long,Cheng, Jin-Pei
, p. 3074 - 3075 (2007/10/03)
Compared with the well-explored enamine catalysis with secondary amines, the development of efficient enamine-based primary amine catalysts has remained as an elusive goal until recently. We present herein that a simple chiral primary-tertiary diamine 1d
