321660-77-9 Usage
Description
FMOC-1,4-DIAMINOBUTANE HYDROCHLORIDE, also known as Fmoc-dab Hydrochloride, is a white crystalline powder with significant chemical properties. It is a derivative of the Fmoc (9-fluorenylmethoxycarbonyl) group, which is commonly used in organic synthesis and peptide chemistry. FMOC-1,4-DIAMINOBUTANE HYDROCHLORIDE is characterized by its reactivity and selectivity, making it a valuable component in various applications.
Uses
Used in Pharmaceutical Industry:
FMOC-1,4-DIAMINOBUTANE HYDROCHLORIDE is used as a reactant for the development of selective activity-based probes for cysteine cathepsins. These probes are essential in understanding the role of cysteine cathepsins in various biological processes and diseases, including cancer and neurodegenerative disorders. FMOC-1,4-DIAMINOBUTANE HYDROCHLORIDE's reactivity and selectivity enable the creation of specific and effective probes, contributing to the advancement of pharmaceutical research and drug development.
Used in Organic Synthesis:
In the field of organic synthesis, FMOC-1,4-DIAMINOBUTANE HYDROCHLORIDE serves as a valuable building block for the synthesis of various complex molecules and compounds. Its unique chemical properties allow for the formation of stable intermediates and final products, facilitating the development of novel chemical entities with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.
Used in Peptide Chemistry:
FMOC-1,4-DIAMINOBUTANE HYDROCHLORIDE is used as a protecting group in peptide synthesis. The Fmoc group is widely employed in solid-phase peptide synthesis (SPPS) due to its ease of removal and compatibility with various coupling agents. FMOC-1,4-DIAMINOBUTANE HYDROCHLORIDE's role as a protecting group ensures the selective protection of the amino group during the synthesis process, allowing for the stepwise assembly of peptides with high purity and yield.
Check Digit Verification of cas no
The CAS Registry Mumber 321660-77-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,1,6,6 and 0 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 321660-77:
(8*3)+(7*2)+(6*1)+(5*6)+(4*6)+(3*0)+(2*7)+(1*7)=119
119 % 10 = 9
So 321660-77-9 is a valid CAS Registry Number.
321660-77-9Relevant articles and documents
Flow-mediated synthesis of Boc, Fmoc, and Dd iv monoprotected diamines
Jong, Thingsoon,Bradley, Mark
supporting information, p. 422 - 425 (2015/03/03)
A series of monoprotected aliphatic diamines (21 examples) were synthesized via continuous flow methods. The carbamates and enamines were obtained in 45-91% yields using a 0.5 mm diameter PTFE tubular flow reactor. Using readily accessible protecting group precursors, the procedure serves as an attractive alternative to existing batch-mode synthetic routes by providing direct, multigram access to N-Boc-, N-Fmoc-, and N-Ddiv-protected compounds with productivity indexes of 1.2-3.6 g/h.
