32174-39-3

Basic information

• Product Name: (R)-m-Methoxymandelic acid
• CAS NO: 32174-39-3
• Molecular Weight: 182.176
• Mol File: 32174-39-3.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: (R)-m-Methoxymandelic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-m-Methoxymandelic acid(32174-39-3)
• EPA Substance Registry System: (R)-m-Methoxymandelic acid(32174-39-3)

Safety Data

• Hazardous Substances Data: 32174-39-3(Hazardous Substances Data)

Upstream product

• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 26767-10-2 2-(3-methoxyphenyl)glyoxylic acid 
• 32174-39-3 3-methoxymandelic acid 
• 108-05-4 vinyl acetate 
• 10049-65-7 (S)-(-)-2-hydroxy-2-(3-methoxyphenyl)acetonitrile 
• 53313-94-3 m-methoxymandelonitrile 
• 591-31-1 3-methoxy-benzaldehyde 
• 586-38-9 3-Methoxybenzoic acid 
• 75-77-4 chloro-trimethyl-silane 
• 151-50-8 potassium cyanide 
• 93554-98-4 3-methoxy-α-[(trimethylsilyl)oxy]benzeneacetonitrile 
• 54845-40-8 methyl 2-hydroxy-2-(3-methoxyphenyl)acetate 
• 2398-37-0 3-methoxyphenyl bromide 
• 83585-22-2 methyl 2-(3-methoxyphenyl)-2-oxoacetate 

Downstream Products

• 21150-12-9 (R)-m-Methoxymandelic acid 
• 54845-40-8 methyl 2-hydroxy-2-(3-methoxyphenyl)acetate 
• 6971-51-3 3-methoxybenzyl alcohol 
• 26767-10-2 2-(3-methoxyphenyl)glyoxylic acid 
• 591-31-1 3-methoxy-benzaldehyde 
• 586-38-9 3-Methoxybenzoic acid 
• 21150-12-9 (S)-2-hydroxy-2-(3-methoxyphenyl)acetic acid 
• 1384954-28-2 C₁₁H₁₂O₅ 
• 32345-57-6 hydroxy-(3-methoxy-phenyl)-acetic acid methyl ester 
• 25698-23-1 D-(-)-3-methoxyphenylglycine 

Relevant articles and documents

The Oxidation of Alcohols by Permanganate. A Comparison with Other High-Valent Transition-Metal Oxidants

The results obtained from a study of the oxidation of mandelic acid and cyclobutanol by permanganate in 1.0 M KOH are best accomodated by a mechanism in which the initial reaction is the addition of a manganese-oxo bond to the α-C-H bond of the alcohol, followed by homolytic cleavage of the resulting Mn-C bond to give free-radical intermediates.A comparison with other high-valent transition-metal oxidants suggests that it is possible to systematically classify the way in which these reagents react with alcohols on the basis of the initial reaction (C-H or O-H addition) and the cleavage mode of the metal-oxygen or metal-carbon bond (homolytic or heterolytic).The approach provides a framework for understanding these reactions that is less chaotic than the current situation where distinctive mechanisms have been proposed for each individual oxidant.

Asymmetric hydrogenation reaction of alpha-ketoacids compound

The invention relates to the technical field of organic chemistry, especially to an asymmetric hydrogenation reaction of an alpha-ketoacids compound. The asymmetric hydrogenation reaction comprises a scheme shown in the description. In the scheme, R1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, C1-C6 alkyl, or aralkyl; a substituent group is C1-C6 alkyl, C1-C6 alkoxy, or halogen; and the number of the substituent group is 1-3. In the scheme, M is a chiral spiro-pyridylamino phosphine ligand iridium complex having a structure shown in the description. In the structure, R is hydrogen, 3-methyl, 4-tBu, or 6-methyl.

Relationships between the racemic structures of substituted mandelic acids containing 8- and 10-membered hydrogen bonded dimer rings

The structures of 27 monosubstituted mandelic acids, including several of their polymorphs, plus unsubstituted mandelic acid itself (two polymorphs) are investigated for structural similarity. The results, presented pictorially as a structural relationship plot, show that rather more structures are built up from the carboxyl-chain hydroxyl hydrogen bonded dimer than from the conventional carboxylic acid dimer. The results show how all the structures are related and, based on the two types of dimer, the degree of similarity that they possess. Some structures with Z′ > 1 contain both sorts of dimers and there are many examples of isostructural sets within the structures so far determined. We also present an example where analysing similarity in related families of structures highlights a structure that should be present and which has indeed then proceeded to be synthesised and determined.