321913-54-6

Basic information

• Product Name: 1-(6-methyl-3-pyridinyl)-2-cyano-2-[(4-methylthio)phenyl]ethanone
• Synonyms: 1-(6-methyl-3-pyridinyl)-2-cyano-2-[(4-methylthio)phenyl]ethanone
• CAS NO: 321913-54-6
• Molecular Weight: 282.366
• Mol File: 321913-54-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(6-methyl-3-pyridinyl)-2-cyano-2-[(4-methylthio)phenyl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-methyl-3-pyridinyl)-2-cyano-2-[(4-methylthio)phenyl]ethanone(321913-54-6)
• EPA Substance Registry System: 1-(6-methyl-3-pyridinyl)-2-cyano-2-[(4-methylthio)phenyl]ethanone(321913-54-6)

Safety Data

• Hazardous Substances Data: 321913-54-6(Hazardous Substances Data)

Usage

Appearance

Yellow crystalline solid

Usage

Pharmaceutical industry as a building block for the synthesis of various drugs

Potential applications

Being studied for its potential use in the treatment of various diseases

Biological activities

Has potential biological activities

Hazardous nature

Can be hazardous to health if not used properly

Versatility

Versatile chemical compound with potential applications in medicine and other fields

Upstream product

• 5470-70-2 Methyl 6-methylnicotinate 
• 38746-92-8 2-[4-(methylsulfanyl)phenyl]acetonitrile 
• 21684-59-3 ethyl 6-methylnicotinate 

Downstream Products

• 221615-72-1 1-(6-methyl-3-pyridinyl)-2-[4-(methyl sulfide)phenyl]ethanone 
• 292067-97-1 5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine 
• 221615-75-4 1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone 
• 202409-33-4 etoricoxib 

Relevant articles and documents

PROCESS FOR CYCLOOXYGENASE-2 SELECTIVE INHIBITOR

The present invention describes a process for preparing a cyclooxygenase-2 selective inhibitor. It provides a synthetic procedure for the said substance namely 5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine of formula (I). The invention also relates to preparation of a new intermediate of formula (IV) and a process to prepare it. Furthermore, the invention describes a process for preparing another key intermediate of formula (II). Compounds of formula (IV) and formula (II) are useful intermediates in synthesis of the said cyclooxygenase-2 inhibitor.

Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone

A five-step process for preparing 1-(6-methylpyridin-3-yl)-2-[(4-(methylsulphonyl)phenyl]-ethanone of the formula starting from 4-(methylthio)benzyl alcohol is described. The compound of the formula I is an intermediate for preparing COX-2 inhibitors, pharmaceutically active compounds having analgesic and antiinflammatory action.