324757-50-8 Usage
Description
R-CLOPIDOGREL CARBOXYLIC ACID is an optically active metabolite of the drug Clopidogrel, which is an off-white solid. It plays a crucial role in the therapeutic effects of Clopidogrel, a medication used to prevent blood clots and reduce the risk of heart attack, stroke, and other cardiovascular events.
Uses
Used in Pharmaceutical Industry:
R-CLOPIDOGREL CARBOXYLIC ACID is used as an active pharmaceutical ingredient for the development of antiplatelet medications. It helps in preventing blood clot formation by irreversibly inhibiting the P2Y12 ADP receptor on platelets, thus reducing the risk of thrombotic events in patients with a history of cardiovascular diseases.
Used in Cardiovascular Health:
R-CLOPIDOGREL CARBOXYLIC ACID is used as a therapeutic agent for the prevention and treatment of cardiovascular conditions such as atherosclerosis, myocardial infarction, and stroke. Its antiplatelet properties help in maintaining blood flow and reducing the risk of clot formation, thereby improving overall cardiovascular health.
Used in Research and Development:
R-CLOPIDOGREL CARBOXYLIC ACID is used as a research compound for studying the mechanism of action, pharmacokinetics, and pharmacodynamics of Clopidogrel. It aids in understanding the drug's effectiveness in preventing blood clots and its potential interactions with other medications, which can contribute to the development of new therapeutic agents and treatment strategies for cardiovascular diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 324757-50-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,4,7,5 and 7 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 324757-50:
(8*3)+(7*2)+(6*4)+(5*7)+(4*5)+(3*7)+(2*5)+(1*0)=148
148 % 10 = 8
So 324757-50-8 is a valid CAS Registry Number.
324757-50-8Relevant articles and documents
PROCESS FOR HIGH YIELD PRODUCTION OF CLOPIDOGREL BY RACEMIZATION OF RESIDUAL LIQUID
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Page/Page column 15, (2008/06/13)
The present invention relates to a process for preparing S-(+)-clopidogrel in high yield by means of racemization of filtrate, and particularly to a process comprising (a) conducting an optical resolution by converting racemic carboxylic acid of clopidogrel to diastereomer salt using (+)-cinchonine, (b) preparing carboxylic acid of S-(+)-clopidogrel by extraction using an appropriate solvent under an acidic condition, (c) preparing optically pure S-(+)-clopidogrel by reacting the carboxylic acid of S-(+)-clopidogrel with methanol, wherein a filtrate, which remains after collecting the diastereomer salt as solid precipitates, is recycled after being converted to a racemic carboxylic acid of clopidogrel via racemization under a basic condition, thereby maximizing the yield of S-(+)-clopidogrel.
