32545-43-0Relevant articles and documents
Quinuclidin-2-ene-based muscarinic antagonists
Hacksell,Nilsson,Nordvall,Johansson,Sundquist,Nilvebrant
, p. 831 - 836 (1995)
A series of achiral 3-heteroaryl substituted quinuclidin-2-ene derivatives and related compounds have been synthesized by facile methods. The compounds were evaluated for muscarinic and antimuscarinic properties in receptor binding studies using (-)-[3H]-QNB as the radioligand and in a functional assay using isolated guinea pig urinary bladder. 3-(2-Benzofuranyl)-quinuclidin-2-ene (15) displayed the highest M1-receptor affinity in the present series (K(i) = 9.6 nM).