327623-37-0 Usage
Description
(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine is a complex organic compound with a unique molecular structure. It is characterized by its chiral centers at the 2nd and 3rd positions, as well as the presence of trifluoromethyl and fluorophenyl groups. (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine has potential applications in various fields due to its unique properties and interactions with biological systems.
Uses
Used in Pharmaceutical Industry:
(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine is used as an impurity in Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. It plays a crucial role in the development and manufacturing process of Aprepitant, ensuring the purity and efficacy of the drug.
Used in Antiemetic Applications:
As an impurity of Aprepitant, (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine contributes to the antiemetic properties of the drug. Aprepitant is primarily used to prevent nausea and vomiting associated with chemotherapy, radiation therapy, and surgery. Its selective action on the NK-1 receptor helps to block the transmission of signals that trigger these symptoms.
Used in Metabolism Studies:
In vitro studies using human liver microsomes have shown that Aprepitant is metabolized primarily by CYP3A4, with minor metabolism by CYP1A2 and CYP2C19. The presence of (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine in Aprepitant may provide insights into the drug's metabolism and potential drug-drug interactions, further enhancing its therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 327623-37-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,7,6,2 and 3 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 327623-37:
(8*3)+(7*2)+(6*7)+(5*6)+(4*2)+(3*3)+(2*3)+(1*7)=140
140 % 10 = 0
So 327623-37-0 is a valid CAS Registry Number.
327623-37-0Relevant articles and documents
Preparation method of NK1 receptor antagonist
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Paragraph 0044-0045, (2021/11/03)
The invention discloses a preparation method of an NK1 receptor antagonist. According to the invention, chiral resolution adopts a mixed solvent, CaCl2 is added for a reaction in an alkaline environment, CaCl2 does not participate in the reaction but needs to be added in advance for better devitrification, water is added for quenching after the reaction is finished, and CaCl2 is dissolved at the same time, so devitrification efficiency is further improved; and then 5-hydroxymethyl-2,4-dihydro-[1,2,4]triazin-3-one is used as a raw material for synthesis of aprepitant under the catalysis of DBU at room temperature.
Synthesis of all enantiomerically pure diastereomers of aprepitant
Gangula, Srinivas,Elati, Chandrashekhar R.,Mudunuru, Satish Varma,Nardela, Anitha,Dongamanti, Ashok,Bhattacharya, Apurba,Bandichhor, Rakeshwar
experimental part, p. 2254 - 2268 (2010/09/11)
Syntheses of all eight enantiomerically pure diastereomers of aprepitant and assignment of absolute configuration at newly generated stereocenters by NMR and X-ray crystallographic analysis were achieved. Copyrigh
