447-43-8

Basic information

• Product Name: 4-FLUOROPHENYLGLYOXAL HYDRATE
• Synonyms: 4-FLUOROPHENYLGLYOXAL HYDRATE;4-FLUOROPHENYLGLYOXAL MONOHYDRATE;2-(4-Fluorophenyl)-2-oxo-acetaldehyde;2-(4-fluorophenyl)-2-oxoacetaldehyde hydrate;4-FLUOROPHENYLGLYOXAL HYDRATE , DRY WT. BASIS;4-FLUOROPHENYLGLYOXAL HYDRATE, 98%, DRY WT. BASIS;2-(4-fluorophenyl)-2-keto-acetaldehyde;2-(4-fluorophenyl)-2-oxo-ethanal
• CAS NO: 447-43-8
• Molecular Formula: C₈H₇FO₃
• Molecular Weight: 170.14
• EINECS: -0
• Mol File: 447-43-8.mol
• Article Data: 33

Chemical Properties

• Melting Point: 80 °C
• Boiling Point: 115 °C
• Flash Point: 80.4 °C
• Appearance: /
• Density: 1.411±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 10.51±0.41(Predicted)
• BRN: 2354778
• CAS DataBase Reference: 4-FLUOROPHENYLGLYOXAL HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROPHENYLGLYOXAL HYDRATE(447-43-8)
• EPA Substance Registry System: 4-FLUOROPHENYLGLYOXAL HYDRATE(447-43-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RTECS: CY1440000
• HazardClass: IRRITANT
• Hazardous Substances Data: 447-43-8(Hazardous Substances Data)

Usage

General Description

4-Fluorophenylglyoxal hydrate is a chemical compound with the molecular formula C8H6F2O4 and a molar mass of 198.126 g/mol. It is a hydrate of 4-fluorophenylglyoxal, and its structure consists of a fluorine-substituted phenyl ring attached to a glyoxal group. 4-FLUOROPHENYLGLYOXAL HYDRATE is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. It is a versatile building block that can participate in various chemical reactions, including condensation, oxidation, and reduction. 4-Fluorophenylglyoxal hydrate is also used in research and development as a reagent and catalyst in organic chemistry. However, it is essential to handle this compound with care, as it may pose health hazards if not properly managed and stored.

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 403-32-7 (4-fluorophenyl)glyoxal 

Downstream Products

• 449-46-7 2-(4-fluorophenyl)quinoxaline 
• 175543-28-9 2,2-diethoxy-1-(4-fluorophenyl)ethanone 
• 1153714-81-8 ethyl (2R,3S)-3-(4-fluorobenzoyl)-1-(4-methoxyphenyl)aziridine-2-carboxylate 
• 1353896-83-9 2-(4-fluorophenyl)-7-(2-(4-fluorophenyl)-4-hydroxy-1-p-tolyl-1H-indol-3-yl)-6,7-dihydro-1-p-tolyl-1H-indol-4(5H)-one 
• 1353896-88-4 1-(4-chlorophenyl)-7-(1-(4-chlorophenyl)-2-(4-fluorophenyl)-4-hydroxy-1H-indol-3-yl)-2-(4-fluorophenyl)-6,7-dihydro-1H-indol-4(5H)-one 
• 1370418-30-6 (E)-1-(4-fluorophenyl)-2-((4-methoxyphenyl)imino)ethanone 
• 1436868-29-9 3-ethoxy-2-(4-fluorophenyl)-6,7-dihydro-6,6-dimethyl-1-phenyl-1H-indol-4(5H)-one 
• 1436868-38-0 2-(4-fluorophenyl)-6,7-dihydro-3-methoxy-6,6-dimethyl-1-p-tolyl-1H-indol-4(5H)-one 
• 1436868-30-2 2-(4-fluorophenyl)-6,7-dihydro-3-methoxy-6,6-dimethyl-1-phenyl-1H-indol-4(5H)-one 
• 327623-37-0 (2S,3R)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine 
• 1185503-48-3 (2S,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine 
• 172822-29-6 5-[{(2S,3R)-2-((1S)-1-3,5-bis(trifluoro-methyl)phenylethoxy)-3-(4-fluorophenyl)-4-morpholinyl}methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one 
• 1185502-97-9 C₂₃H₂₁F₇N₄O₃ 
• 1579293-00-7 N-cyclohexyl-3-(4-fluorophenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydrocinnoline-4-carboxamide 

Relevant articles and documents

One-pot, three-component synthesis of polyfunctionalized benzo[h]pyrazolo[3,4-b][1,6]naphthyridine and benzo[g]pyrazolo[3,4-b]quinoline derivatives in the presence of silver nanoparticles (AgNPs)

An efficient and straightforward protocol for one-pot, three-component reaction of aryl glyoxal monohydrates 1a-h, 5-amino-1-aryl-3-methylpyrazoles 2a,b and 4-hydroxyquinoline-2(1H)-one (3) or 2-hydroxy-1,4-naphthoquinone (4) using silver nanoparticles (AgNPs) as a high performance nanocatalyst in H2O/EtOH at 60°C afforded the corresponding polyfunctionalized benzo[h]pyrazolo[3,4-b][1,6]naphthyridines 5a-h and benzo[g]pyrazolo[3,4-b]quinolines 6a-i, respectively. Excellent catalytic activity, high yields, employing green media and green nanocatalyst, cost-effective and simple procedure are some notable advantages of using AgNPs as a noble metal nanocatalyst in this synthetic strategy. The structures of fused heterocycles were confirmed by their Fourier transform infrared, proton nuclear magnetic resonance (1H-NMR), and 13C-NMR spectral data and microanalysis.

Preparation methods of aprepitant impurity

The invention discloses preparation methods of an aprepitant impurity, which comprise isomer impurity synthesis method of six aprepitant key intermediates (2R, 3S)-2-[(1R)-1-[3, 5-bis (trifluoromethyl)-phenyl] ethoxy]-3-(4-fluorophenyl) morpholine, respectively, synthesis of four diastereomer impurities, synthesis of one enantiomer impurity and synthesis of one by-product impurity. The methods have the beneficial effects that the five synthesis methods are simple and feasible, the raw materials are easy to obtain, the conditions are mild, the cost is low, the production is facilitated, and meanwhile, the isomer impurities of the synthesized aprepitant key intermediate provide a new intermediate raw material for the preparation of aprepitant.

A simple protocol for the green synthesis of a new series of pyrimido[4,5b][1,6]naphthyridines in the presence of silver nanoparticles (AgNPs)

Eight polyfunctionalized pyrimidonaphthyridine derivatives has been synthesized, in 79-92% yields, via the one-pot, three-component reaction of aryl glyoxal monohydrates, 6-aminouracil and 4-hydroxyquinolin-2(1H)-one in H2O/EtOH in the presence of AgNPs under mild conditions. In this work colloidal AgNPs acts as an efficient, economical, green nanocatalyst, leading to a simple method of preparation.