328575-54-8

Basic information

• Product Name: (2S,2'S,5'S)-[2',5'-Bis(methoxymethyl)-2',3',4',5'-tetrahydro-1'H-pyrrol-1'-yl](2-benzyl-3-methyl-2,5-dihydrofuran-2-yl)methanone
• CAS NO: 328575-54-8
• Molecular Weight: 359.466
• Mol File: 328575-54-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,2'S,5'S)-[2',5'-Bis(methoxymethyl)-2',3',4',5'-tetrahydro-1'H-pyrrol-1'-yl](2-benzyl-3-methyl-2,5-dihydrofuran-2-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,2'S,5'S)-[2',5'-Bis(methoxymethyl)-2',3',4',5'-tetrahydro-1'H-pyrrol-1'-yl](2-benzyl-3-methyl-2,5-dihydrofuran-2-yl)methanone(328575-54-8)
• EPA Substance Registry System: (2S,2'S,5'S)-[2',5'-Bis(methoxymethyl)-2',3',4',5'-tetrahydro-1'H-pyrrol-1'-yl](2-benzyl-3-methyl-2,5-dihydrofuran-2-yl)methanone(328575-54-8)

Safety Data

• Hazardous Substances Data: 328575-54-8(Hazardous Substances Data)

Upstream product

• 4412-96-8 3-methylfuran-2-carboxylic acid 
• 22601-06-5 3-methylfuran-2-carbonyl chloride 
• 100-39-0 benzyl bromide 
• 207912-01-4 (2'S,5'S)-[2',5'-Bis(methoxymethyl)-2',3',4',5'-tetrahydro-1'H-pyrrol-1'-yl](3-methyl-2-furyl)methanone 

Relevant articles and documents

Stereoselective reduction of chiral 2-furoic acid derivatives using group I metals in ammonia

A series of chiral auxiliaries have been attached to 2-furoic acid and 3-methyl-2-furoic acid. The performance of these auxiliaries in the Birch reduction was assessed and it was found that placing a C-3 methyl group on the heterocycle was essential for good stereoselectivity. Using bis(methoxymethyl)pyrrolidine high levels of diastereoselectivity could be obtained with a range of electrophiles. A model is also presented which explains the sense of stereoselectivity displayed by this auxiliary. After reduction, the auxiliaries could be removed by reaction with acid to furnish dihydrofuran-based carboxylic acids with high enantiomeric excess. The Royal Society of Chemistry 2000.