329076-64-4

Basic information

• Product Name: 2-(4-fluorophenyl)-2-(4-methylsulfonylbenzoyl)acetic acid ethyl ester
• Synonyms: 2-(4-fluorophenyl)-2-(4-methylsulfonylbenzoyl)acetic acid ethyl ester
• CAS NO: 329076-64-4
• Molecular Weight: 364.394
• Mol File: 329076-64-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-2-(4-methylsulfonylbenzoyl)acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-2-(4-methylsulfonylbenzoyl)acetic acid ethyl ester(329076-64-4)
• EPA Substance Registry System: 2-(4-fluorophenyl)-2-(4-methylsulfonylbenzoyl)acetic acid ethyl ester(329076-64-4)

Safety Data

• Hazardous Substances Data: 329076-64-4(Hazardous Substances Data)

Upstream product

• 587-88-2 ethyl 2-(4-fluorophenyl)acetate 
• 40913-92-6 4-methylsulfonylbenzoyl chloride 
• 405-50-5 p-Fluorophenylacetic acid 

Downstream Products

• 791806-41-2 3-(4,4-diethoxy-tetrahydro-pyran-3-yloxy)-4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazole 
• 329076-08-6 3-(4-fluorophenacyloxy)-4-(4-fluorophenyl)-5-(4-methanesulfonylphenyl)pyrazole 
• 329075-87-8 2-{[4-(4-fluorophenyl)-5-(4-(methylsulphonyl)phenyl)-1H-pyrazol-3-yl]oxy}cyclohexanone 
• 329076-23-5 ethyl 7-(4-Fluorophenyl)-6-(4-methylsulfonylphenyl)-3-methylpyrazolo[5,1-b][1,3]oxazole-2-carboxylate 
• 329076-69-9 4-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)-3-(tetrahydro-4H-pyran-4-on-3-yloxy)pyrazole 

Relevant articles and documents

THIONE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

A 1,2,4-triazole derivative of formula (1) or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.

Synthesis of 4,5-Diaryl-1H-pyrazole-3-ol derivatives as potential COX-2 inhibitors

4,5-Diaryl-1H-pyrazole-3-ol was utilized as a versatile template to synthesize several classes of compounds such as pyrazolo-oxazines 7, pyrazolo-benzooxazines 9, pyrazolo-oxazoles 10, and its analogues 11a-c as potential COX-2 inhibitors. Compounds 11b,c were successfully synthesized with use of pyridinium p-toluenesulfonate mediated cyclization of the ketal intermediate. Diarylpyrazolo-benzooxazepine analogues were synthesized by using Cu-mediated cyclization of the O-alkylated arylbromide intermediate. Arylsulfonamides were synthesized efficiently on a large scale with 4-[4-(4-fluorophenyl)-5-hydroxy-2H-pyrazol-3-yl]benzenesulfonamide 31 template readily synthesized from commercially available 4-sulfamoyl benzoic acid 29. The structure of a representative compound from each class was confirmed by X-ray crystallography. Selected compounds tested for inhibitory activity against COX-1 and COX-2 enzymes showed good selectivity for COX-2 versus COX-1 enzyme.