32981-89-8Relevant articles and documents
Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents
Ojima, Iwao,Borella, Christopher P.,Wu, Xinyuan,Bounaud, Pierre-Yves,Oderda, Cecilia Fumero,Sturm, Matthew,Miller, Michael L.,Chakravarty, Subrata,Chen, Jin,Huang, Qing,Pera, Paula,Brooks, Tracy A.,Baer, Maria R.,Bernacki, Ralph J.
, p. 2218 - 2228 (2007/10/03)
A series of novel taxane-based multidrug resistance (MDR) reversal agents (TRAs) has been designed and synthesized. Structure - activity relationship (SAR) study clearly indicates that modification of the C-7 position with hydrophobic arenecarbonylcinnamoyl groups brings about high potency against drug efflux mediated by P-glycoprotein (P-gp). Six TRAs exhibit ability to modulate a wide range of ATP-binding cassette (ABC) transporters, such as P-gp, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein (BCRP), which may serve as novel broad-spectrum modulators of ABC transporters.
A mild and efficient approach for the deprotection of silyl ethers by sodium periodate
Wang, Mijuan,Li, Chun,Yin, Dali,Liang, Xiao-Tian
, p. 8727 - 8729 (2007/10/03)
A mild and efficient method for the deprotection of silyl ethers is reported. The most often used silyl protecting groups, such as TBDMS, TIPS, TMS, TES, TIBS, TPS can be cleaved by NaIO4 furnishing the corresponding alcohol in high yields. This method can be used for a wide range of substrates.
Anitleukemic Alkaloids from Taxus wallichiana Zucc.
Miller, Roger W.,Powell, Richard G.,Smith, Cecil R.
, p. 1469 - 1474 (2007/10/02)
A new antileukemic taxane alkaloid, cephalomannine (1a), has been isolated from leaves, stems, and roots of Taxus wallichiana Zucc.Cephalomannine is closely related to taxol (1b), a previously characterized antileukemic alkaloid, which also occurs in T. wallichiana but in lesser amounts than cephalomannine.The new alkaloid and its hydrolysis products were characterized by nuclear magnetic resonance, mass spetroscopy, and X-ray crystallography; taxol and two cytotoxic taxane congeners were also identified.