518021-32-4

Basic information

• Product Name: C₃₆H₄₄O₁₃
• Synonyms: C₃₆H₄₄O₁₃
• CAS NO: 518021-32-4
• Molecular Weight: 684.738
• Mol File: 518021-32-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₆H₄₄O₁₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₆H₄₄O₁₃(518021-32-4)
• EPA Substance Registry System: C₃₆H₄₄O₁₃(518021-32-4)

Safety Data

• Hazardous Substances Data: 518021-32-4(Hazardous Substances Data)

Upstream product

• 32981-89-8 13-oxobaccatin III 
• 24424-99-5 di-tert-butyl dicarbonate 
• 32981-86-5 10-deacetylbaccatin III 
• 27548-93-2 baccatin III 
• 92950-42-0 13-dehydro-10-deacetylbaccatin III 

Downstream Products

• 518021-34-6 C₃₇H₄₂O₁₅ 
• 518021-33-5 C₃₆H₄₄O₁₄ 

Relevant articles and documents

Diastereoselective 14beta-hydroxylation of baccatin III derivatives.

14beta-Hydroxybaccatin III, a compound with limited availability by natural sources, is the starting material for the synthesis of the second-generation anticancer taxoid ortataxel. The 7-tert-butoxycarbonyl (1a) and 7-triethylsilyl (1b) derivatives of 14beta-hydroxybaccatin III 1,14-carbonate were synthesized from 10-deacetylbaccatin III (3). The crucial steps were (a) the C(14)beta hydroxylation of the corresponding 13-oxobaccatin III derivatives by oxaziridine-mediated electrophilic oxidation and (b) the reduction of the C(13) carbonyl group with sodium or alkylammonium borohydrides. This protocol provides a practical way for the semisynthesis of ortataxel from 10-deacetylbaccatin III, a compound readily available from various yews.