330942-01-3

Basic information

• Product Name: N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide
• Synonyms: N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide;N-(5-chloropyridin-2-yl)-2-(4-cyanobenzaMido)-5-MethoxybenzaMide;Benzamide, N-(5-chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxy-
• CAS NO: 330942-01-3
• Molecular Formula: C₂₁H₁₅ClN₄O₃
• Molecular Weight: 406.8218
• Product Categories: Betrixaban
• Mol File: 330942-01-3.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 504.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.42±0.1 g/cm3 (20 ºC 760 Torr)
• PKA: 11.00±0.70(Predicted)
• CAS DataBase Reference: N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide(330942-01-3)
• EPA Substance Registry System: N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide(330942-01-3)

Safety Data

• Hazardous Substances Data: 330942-01-3(Hazardous Substances Data)

Usage

General Description

N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide is a chemical compound with a complex structure that includes a chloropyridinyl group, a cyanobenzoyl group, and a methoxybenzamide group. It is commonly used in research and development of pharmaceuticals, particularly in the study of potential drug candidates for the treatment of various diseases. N-(5-Chloro-2-pyridinyl)-2-[(4-cyanobenzoyl)amino]-5-methoxybenzamide may have potential therapeutic effects due to its molecular structure and chemical properties, and further studies are needed to fully understand its biological activities and potential applications in medicine.

Upstream product

• 619-65-8 4-cyanobenzoic Acid 
• 1072-98-6 5-chloro-2-pyridylamine 
• 1882-69-5 5-methoxy-2-nitro-benzoic acid 
• 6068-72-0 4-cyanobenzoyl chlorIde 
• 280773-16-2 5-methoxy-2-nitro-N-(5-chloro-pyridine-2-yl)benzamide 
• 504-29-0 2-aminopyridine 
• 1616693-67-4 C₁₃H₁₁N₃O₄ 
• 280773-17-3 2-amino-N-(5-chloro-pyridin-2-yl)-5-methoxy-benzamide 
• 64459-25-2 4-cyanophenyl chloroformate 
• 40465-45-0 p-cyanophenyl isocyanate 

Downstream Products

• 936539-81-0 N-(5-chloro-2-pyridinyl)-2-((4-cyanobenzoyl)amino)-5-methoxybenzamide hydrochloride 
• 330942-05-7 betrixaban 
• 936539-80-9 N-(5-chloropyridin-2-yl)-2-[4-(N,N-dimethylcarbamimidoyl)benzamido]-5-methoxybenzamide maleic acid salt 
• 330942-22-8 ethyl 2-{3-[N-(5-chloro(2-pyridyl))carbamoyl]-4-[(4-cyanophenyl)carbonylamino]phenoxy}acetate 
• 330942-21-7 N-(5-chloro(2-pyridyl)){6-[(4-cyanophenyl)carbonylamino]-3-hydroxyphenyl}carboxamide 

Relevant articles and documents

A facile method for the synthesis of Betrixaban

A facile method for the synthesis of N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide (Betrixaban) from 5-methoxy-2-nitrobenzoic acid is achieved by reduction, acylation, chlorination, acylation and the formation of the amidine. A dechlorinated impurity is avoided in this method. Using tetrahydrofuran as the solvent in the four steps makes its recovery easier. The total yield of the target compound is about 40% and this method is suitable for large-scale production.

Improved preparation method of beta-caraban

The invention relates to the fields of organic chemistry and pharmacy, and particularly relates to an improved method for preparing betrixaban. Compared with the prior art, the method has the advantages that the defects of use of high-corrosion hydrogen chloride gas, heavy burden for 'three wastes' treatment, difficult refining and purification of products and the like can be overcome. The method is characterized in that a metal organic compound RMR' (M is selected from Mg and Zn, R is selected from Cl, Br, I, alkyl or aryl, and R' is selected from akly or aryl) is used for reacting with dimethylamine or salt thereof in an aprotic solvent; then the obtained reacting liquid reacts with the compound or salt thereof in a formula II to prepare betrixaban. The improved novel method has the advantages of use of easily available raw materials, mild reaction condition, convenience in operation, excellent product quality and low cost and is suitable for industrial large-scale production.

SALTS OF BETRIXABAN AND PROCESSES FOR PREPARATION THEREOF

The present application relates to novel acid addition salts of Betrixaban and processes for their preparation thereof. It further relates to crystalline forms including its solvates and hydrates of Betrixaban novel acid addition salts. The application further concerns pharmaceutical compositions comprising the novel acid addition salts of the Betrixaban, useful as potent fXa inhibitors.