3312-04-7

Basic information

• Product Name: 1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE)
• Synonyms: 1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE);1-chloro-4,4-bis(4-fluorophenyl)butane;Tech.90%;4,4-Bis(4-fluorophenyl)butyl chloride.;1,1''-(4-CHLOROBUTYLIDENE)BIS-(4-FLUOROBENZENE) TECH 90%;1,1'-(4-Chlorobutylidene)bis-(4-fluorobenzene) tech. 90%;1,1-Bis(4-fluorophenyl)-4-chlorobutane;1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene),90%,tech.
• CAS NO: 3312-04-7
• Molecular Formula: C₁₆H₁₅ClF₂
• Molecular Weight: 280.74
• EINECS: 221-998-6
• Mol File: 3312-04-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 128 °C (0.1 mmHg)
• Flash Point: 187 °C
• Appearance: /
• Density: 1.2
• Vapor Pressure: 0.01Pa at 25℃
• Refractive Index: 1.541-1.545
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Water Solubility: 181.3μg/L at 25℃
• CAS DataBase Reference: 1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE)(3312-04-7)
• EPA Substance Registry System: 1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE)(3312-04-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 3312-04-7(Hazardous Substances Data)

Usage

Description

1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE), also known as a derivative of Zerumbone, is a chemical compound characterized by its yellow to brown liquid appearance. It possesses potential anti-tumor effects, particularly towards HeLa cancer cells, making it a promising candidate for pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE) is used as an anti-tumor agent for its potential effects against HeLa cancer cells. 1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE)'s ability to target and potentially inhibit the growth of these cancer cells makes it a valuable asset in the development of novel cancer treatments.
Additionally, due to its chemical properties and potential anti-tumor effects, 1,1'-(4-CHLOROBUTYLIDENE)BIS(4-FLUOROBENZENE) may also be utilized in other industries for various applications, such as in the development of new drug delivery systems or as a component in the synthesis of other pharmaceutical compounds. However, further research and development would be necessary to fully explore and understand its potential applications in these areas.

Flammability and Explosibility

Notclassified

Upstream product

• 405-99-2 para-fluorostyrene 
• 19263-25-3 3-chloropropionyl peroxide 
• 1765-93-1 4-fluoroboronic acid 
• 345-92-6 4,4'-Difluorobenzophenone 
• 50337-85-4 4,4-bis(4-fluorophenyl)butan-1-ol 
• 427-53-2 cyclopropylbis(4-fluorophenyl)methanol 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 51787-82-7 8-[4,4-bis-(4-fluoro-phenyl)-butyl]-1,4-dioxa-8-aza-spiro[4.5]decane 
• 387826-59-7 N-(3-{1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl}phenyl)-2-methylpropanamide 
• 58859-80-6 1-{1-[4,4-bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-5-iodo-1,3-dihydro-benzoimidazol-2-one 
• 59045-48-6 5-chloro-1-{1-[4,4-bis(4-fluorophenyl)butyl]-2-methyl-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one 
• 59834-42-3 4-(p-FLUOROBENZOYL)-1-[4,4-(DI-p-FLUOROPHENYL)-BUTYL]PIPERIDINE HYDROBROMIDE 
• 59834-46-7 4-(p-FLUOROBENZOYL)-4-HYDROXY-1-[4,4-(DI-p-FLUOROPHENYL)-BUTYL]PIPERIDINE OXALATE 
• 31633-84-8 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chlorophenyl)piperidin-4-ol 
• 134070-16-9 8-[4,4-Bis-(4-fluoro-phenyl)-butyl]-4-hydroxy-4-methyl-3-naphthalen-1-yl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one; hydrochloride 
• 134069-56-0 1-oxa-2-oxo-3-decyl-4-hydroxy-4-methyl-8-[ 4,4-bis(4-fluorophenyl)butyl]-3,8-diazaspiro[ 4,5]decane hydrochloride 
• 134070-20-5 8-[4,4-Bis-(4-fluoro-phenyl)-butyl]-3-cyclohexyl-4-hydroxy-4-methyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one; hydrochloride 
• 134070-21-6 8-[4,4-Bis-(4-fluoro-phenyl)-butyl]-4-hydroxy-3-isopropyl-4-methyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one; hydrochloride 
• 134070-22-7 8-[4,4-Bis-(4-fluoro-phenyl)-butyl]-4-hydroxy-4-methyl-3-propyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one; hydrochloride 
• 230297-18-4 3,3-di-(4-fluorophenyl)propanal 
• 61668-03-9 1,1'-(but-1-ene-4,4-diyl)bis(4-fluorobenzene) 

Relevant articles and documents

Alkylation-arylation method and application of olefin compound

The invention discloses an alkyl-arylation method of an olefin compound. The method comprises the following steps: reacting a reaction system comprising a compound a as shown in a formula II, a compound b as shown in a formula III and a compound c as shown in a formula IV to prepare a compound I as shown in a formula I; wherein R1 is selected from one of alkyl, substituted alkyl, heteroaryl and substituted heteroaryl; Ar is selected from one of aryl, substituted aryl, heteroaryl and substituted heteroaryl; R2 is selected from one of alkyl, substituted alkyl, heteroaryl and substituted heteroaryl. The invention further provides application of the method. According to the method provided by the invention, the cheap and easily available catalyst is adopted, the reaction condition is mild, the method is green and environment-friendly, the selectivity and yield of the product are relatively high, a simple and effective method is provided for the field of organic synthesis to obtain the expensive alkyl harmonic diaryl compound, and the method has wide research value and industrial application prospect.

PROCESS FOR THE PREPARATION OF A FLUSPIRILENE INTERMEDIATE

The present invention relates to a process for the preparation of a 4,4'- bis(fluorobenzene) derivative, which is an intermediate compound in the synthesis of some drugs, for example in the synthesis of fluspirilene. The invention further relates to new synthetic intermediate compounds.