33420-52-9

Basic information

• Product Name: 2,2-DIFLUOROPROPANOL
• Synonyms: 2,2-DIFLUOROPROPANOL;2,2-DIFLUORO-PROPAN-1-OL;2,2-Difluoro-1-hydroxypropane;2,2-Difluoropropanol, 98%+;2,2-Difluoro-1-propanol;2,2-difuoropropanol
• CAS NO: 33420-52-9
• Molecular Formula: C₃H₆F₂O
• Molecular Weight: 96.08
• Mol File: 33420-52-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 97-99
• Flash Point: 31℃
• Appearance: /
• Density: 1.2
• Refractive Index: n20/D1.349
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 13.91±0.10(Predicted)
• CAS DataBase Reference: 2,2-DIFLUOROPROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIFLUOROPROPANOL(33420-52-9)
• EPA Substance Registry System: 2,2-DIFLUOROPROPANOL(33420-52-9)

Safety Data

• Hazard Codes: F,Xn
• Statements: 10-22-36/37/38
• Safety Statements: 26
• RIDADR: UN 1987C 3 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 33420-52-9(Hazardous Substances Data)

Usage

Description

2,2-Difluoropropanol is a colorless liquid that serves as a versatile compound in various industries due to its unique chemical properties.

Uses

Used in Organic Synthesis:
2,2-Difluoropropanol is used as a reagent for the synthesis of various organic compounds, leveraging its unique chemical properties to facilitate reactions and produce desired products.
Used in Pharmaceutical Intermediates:
2,2-Difluoropropanol is used as an intermediate in the development of pharmaceuticals, contributing to the creation of new drugs and medications that can address various health concerns.

Upstream product

• 38650-84-9 methyl 2,2-difluoropropionate 
• 784193-14-2 Benzoic acid 2,2-difluoropropyl ester 
• 97006-65-0 2,2-difluoropropyl fluorosulfite 
• 26438-85-7 3-chloro-2-fluoro-1-propanol 

Downstream Products

• 1532517-71-7 C₉H₈BrF₂NO₃ 
• 1268475-14-4 2,2-difluoropropyl 4-nitrobenzenesulfonate 
• 1262400-01-0 2,2-difluoropropyl 4-methylbenzenesulfonate 

Relevant articles and documents

Α, α-difluoropropionic production of esters

PROBLEM TO BE SOLVED: To provide a practical method of producing α,α-difluoro esters important as pharmaceutical and agricultural chemical intermediates. SOLUTION: The α,α-difluoro esters are produced by reacting α-halogeno-α-fluoro esters with salts or complexes comprising an organic base and hydrogen fluoride. Dehydrohalogenation of side reaction is controlled in the production method. Only α-fluoro-α,β-unsaturated esters of by-products are treated to be brought specifically into a high boiling-point, a boiling point difference gets remarkably large thereby between the α,α-difluoro ester of an objective product and the unsaturated ester of by-product, and a high purity product of the objective product is efficiently obtained by fractional distillation of a simple operation. The method is the practical method of producing the α,α-difluoro esters capable of solving a problem point in a prior technique. COPYRIGHT: (C)2012,JPOandINPIT

Practical selective hydrogenation of α-fluorinated esters with bifunctional pincer-type ruthenium(II) catalysts leading to fluorinated alcohols or fluoral hemiacetals

Selective hydrogenation of fluorinated esters with pincer-type bifunctional catalysts RuHCl(CO)(dpa) 1a, trans-RuH2(CO)(dpa) 1b, and trans-RuCl2(CO)(dpa) 1c under mild conditions proceeds rapidly to give the corresponding fluorinated alcohols or hemiacetals in good to excellent yields. Under the optimized conditions, the hydrogenation of chiral (R)-2-fluoropropionate proceeds smoothly to give the corresponding chiral alcohol without any serious decrease of the ee value.

New bicyclic cannabinoid receptor-1 (CB1-R) antagonists

A series of conformationally constrained bicyclic derivatives derived from SR141716 was prepared and evaluated as hCB1-R antagonists and inverse agonists. Optimization of the structure-activity relationships around the 2,6-dihydro-pyrazolo[4,3-