335595-52-3

Basic information

• Product Name: (R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid
• Synonyms: (R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid
• CAS NO: 335595-52-3
• Molecular Weight: 230.26
• Mol File: 335595-52-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid(335595-52-3)
• EPA Substance Registry System: (R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid(335595-52-3)

Safety Data

• Hazardous Substances Data: 335595-52-3(Hazardous Substances Data)

Upstream product

• 371-42-6 4-Fluorothiophenol 
• 261904-39-6 (2R)-3-bromo-2-hydroxy-2-methylpropanoic acid 

Downstream Products

• 890658-79-4 C₁₀H₁₁FO₅S 
• 937802-59-0 bicalutamide 
• 90357-06-5 (R)-bicalutamide 

Relevant articles and documents

Preparation method of (R)-bicalutamide intermediate

The invention relates to a method for preparing an (R)-bicalutamide intermediate. The method comprises the following steps: taking methacrylic acid as a raw material, and obtaining the (R)-bicalutamide intermediate through several steps of esterification, hydroxylation and sulfonation, namely, (R)-3-(4-fluorophenylsulfydryl)-2-hydroxy-2-methylpropionic acid. (R)-bicalutamide with enantioselectivity of more than 99% can be obtained by two simple follow-up reactions of the intermediate. The preparation method has the advantages of easily available starting materials, high reaction yield, easy operation in reaction, high enantioselectivity and wide industrial application prospects.

SELECTIVE ANDROGEN RECEPTOR MODULATORS, ANALOGS AND DERIVATIVES THEREOF AND USES THEREOF

This invention provides new compounds and uses thereof in treating a variety of diseases or conditions in a subject, including,inter alia, prostate cancer, muscle wasting diseases and/or disorders or a bone-related diseases and/or disorders.