890658-79-4

Basic information

• Product Name: Propanoic acid, 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (2R)-
• CAS NO: 890658-79-4
• Molecular Formula: C10H11FO5S
• Molecular Weight: 262.259
• Mol File: 890658-79-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (2R)-(890658-79-4)
• EPA Substance Registry System: Propanoic acid, 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-, (2R)-(890658-79-4)

Safety Data

• Hazardous Substances Data: 890658-79-4(Hazardous Substances Data)

Upstream product

• 928312-15-6 C₁₀H₁₃FO₄S 
• 928312-13-4 C₁₇H₁₉FO₂S 
• 928312-14-5 C₁₇H₁₉FO₄S 
• 371-42-6 4-Fluorothiophenol 
• 335595-52-3 (R)-3-(4-fluorophenylmercapto)-2-hydroxy-2-methylpropionic acid 
• 824-80-6 sodium 4-fluorobenzenesulfinate 

Downstream Products

• 90357-06-5 (R)-bicalutamide 

Relevant articles and documents

Catalytic Decarboxylative Radical Sulfonylation

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Bacillus subtilis epoxide hydrolase-catalyzed preparation of enantiopure 2-methylpropane-1,2,3-triol monobenzyl ether and its application to expeditious synthesis of (R)-bicalutamide

Expeditious synthesis of (R)-bicalutamide (1), a synthetic antiandrogen, from enantiopure 2-methylpropane-1,2,3-triol monobenzyl ether (4) was achieved. An engineered Bacillus subtilis epoxide hydrolase worked enantioselectively on the racemic epoxide (7) to provide the above starting material in highly enantiomerically enriched state.