335654-06-3 Usage
Description
2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE is an intermediate pyrrolo-pyrimidine compound that serves as a crucial building block in the synthesis of various pharmaceuticals, particularly those targeting tyrosine kinases. Its unique chemical structure allows for the development of potent and selective inhibitors, making it a valuable asset in the field of medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE is used as an intermediate compound for the development of tyrosine kinase inhibitors. These inhibitors play a vital role in the treatment of various diseases, including cancer, by targeting and disrupting the activity of specific tyrosine kinases involved in cell signaling pathways.
Used in the Preparation of STAT6 Inhibitors:
2-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE is also used as an intermediate in the synthesis of oral signal transducers and activators of transcription 6 (STAT6) inhibitors. STAT6 is a transcription factor that plays a significant role in the regulation of immune responses and has been implicated in the pathogenesis of various diseases, including autoimmune disorders and cancer. By inhibiting STAT6, these compounds can potentially modulate immune responses and offer therapeutic benefits in treating these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 335654-06-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,5,6,5 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 335654-06:
(8*3)+(7*3)+(6*5)+(5*6)+(4*5)+(3*4)+(2*0)+(1*6)=143
143 % 10 = 3
So 335654-06-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H4ClN3/c7-6-9-3-4-1-2-8-5(4)10-6/h1-3H,(H,8,9,10)
335654-06-3Relevant articles and documents
Preparation method of 5-bromo-2-chloro-7H-pyrrolo [2, 3-d] pyrimidine
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Paragraph 0008; 0022-0024, (2020/05/08)
The invention discloses a preparation method of 5-bromo-2-chloro-7H-pyrrolo[2, 3-b] pyridine. According to the method, 2,4-chloro-7H-pyrrolo[2, 3-d] pyrimidine is used as a starting raw material, in the presence of zinc powder and acetic acid, selective d
Method for selective dehalogenation in pyrimidine fused ring
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Paragraph 0030; 0031; 0032, (2016/10/10)
The invention discloses a method for selective dehalogenation in pyrimidine fused ring. Through heating reaction between zinc powder and acetic acid solution, selective dehalogenation is conducted on pyrimidine ring to maintain original substituents on pyrimidine ring and fused ring. The method comprises few operation steps with high yield, and is applicable to mass production.
COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS
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Page/Page column 73, (2015/03/28)
The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating FAK and/or Src activity by administering a therapeutically effective amount of one or more of the compounds to a subject. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the FAK and/or Src pathway. Advantageously, these compounds perform as dual FAK and/or Src inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.
