33567-59-8Relevant articles and documents
Synthetic Access to gem-Difluoropropargyl Vinyl Ethers and Their Application to Propargyl Claisen Rearrangement
Okamura, Toshitaka,Koyamada, Kenta,Kanazawa, Junichiro,Miyamoto, Kazunori,Iwabuchi, Yoshiharu,Uchiyama, Masanobu,Kanoh, Naoki
, p. 1911 - 1924 (2020/12/23)
With the increasing importance of fluorine to medicinal chemistry and other areas, methods to access various fluorinated compounds are needed. Herein, we report the synthesis of difluoropropargyl vinyl ethers from ketones and aldehydes using difluoropropargyl bromide dicobalt complexes. We applied difluoropropargyl vinyl ethers to the synthesis of difluorodienone or difluoroallene under thermal conditions and trifluoro-pyran under acid-catalyzed conditions.
Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase
Takahara, Satoyuki,Nakagawa, Kiyomi,Uchiyama, Tsugumi,Yoshida, Tomoyuki,Matsumoto, Kazunori,Kawasumi, Yasuo,Mizuguchi, Mineyuki,Obita, Takayuki,Watanabe, Yurie,Hayakawa, Daichi,Gouda, Hiroaki,Mori, Hisashi,Toyooka, Naoki
supporting information, p. 441 - 445 (2017/12/28)
Most of the endogenous free D-serine (about 90%) in the brain is produced by serine racemase (SR). D-Serine in the brain is involved in neurodegenerative disorders and epileptic states as an endogenous co-agonist of the NMDA-type glutamate receptor. Thus, SR inhibitors are expected to be novel therapeutic candidates for the treatment of these disorders. In this study, we solved the crystal structure of wild-type SR, and tried to identify a new inhibitor of SR by in silico screening using the structural information. As a result, we identified two hit compounds by their in vitro evaluations using wild-type SR. Based on the structure of the more potent hit compound 1, we synthesized 15 derivatives and evaluated their inhibitory activities against wild-type SR. Among them, the compound 9C showed relatively high inhibitory potency for wild-type SR. Compound 9C was a more potent inhibitor than compound 24, which was synthesized by our group based upon the structural information of the mutant-type SR.
Pyrrole marine alkaloid Neolamellarin A analogs and its preparation method and application
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Paragraph 0073; 0074; 0076, (2017/10/27)
The invention relates to pyrrole ocean alkaloids Neolamellarin A analogues as shown in the formula I and a preparation method and application thereof. Experiments show that, some of the pyrrole ocean alkaloids Neolamellarin A analogues have strong inhibitory effect on tumor cell lines; some of the pyrrole ocean alkaloids Neolamellarin A analogues have very good neuro cell protective effect; and some of the pyrrole ocean alkaloids Neolamellarin A analogues have very strong inhibitory effect on heat shock protein Hsp90.
