33592-56-2

Basic information

• Product Name: 1-METHANESULFONYL-4-PHENYLETHYNYL-BENZENE
• Synonyms: 1-METHANESULFONYL-4-PHENYLETHYNYL-BENZENE
• CAS NO: 33592-56-2
• Molecular Formula: C₁₅H₁₂O₂S
• Molecular Weight: 256.31958
• Mol File: 33592-56-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-METHANESULFONYL-4-PHENYLETHYNYL-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHANESULFONYL-4-PHENYLETHYNYL-BENZENE(33592-56-2)
• EPA Substance Registry System: 1-METHANESULFONYL-4-PHENYLETHYNYL-BENZENE(33592-56-2)

Safety Data

• Hazardous Substances Data: 33592-56-2(Hazardous Substances Data)

Usage

Physical state

White solid at room temperature.

Solubility

Highly soluble in organic solvents.

Usage

Often used in the synthesis of organic and medicinal compounds.

Versatility

A valuable building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals.

Chemical properties

Possesses strong electron-withdrawing properties due to the presence of the sulfonyl and ethynyl groups.

Bond formation

Useful in the formation of carbon-carbon and carbon-heteroatom bonds.

Structural features

Unique structure and chemical properties that make MSPEB a valuable tool in the field of organic chemistry.

Upstream product

• 3466-32-8 4-bromoohenyl methyl sulfone 
• 536-74-3 phenylacetylene 
• 33533-42-5 1-[4-(methylsulfanyl)phenyl]-2-phenylacetylene 
• 13146-23-1 copper(I) phenylacetylenide 
• 64984-08-3 1-iodo-4-(methylsulfonyl)benzene 

Downstream Products

• 54945-18-5 1-(4-methanesulfonyl-phenyl)-2-phenyl-ethane-1,2-dione 

Relevant articles and documents

Ligand-free (: Z)-selective transfer semihydrogenation of alkynes catalyzed by in situ generated oxidizable copper nanoparticles

Herein, we present (Z)-selective transfer semihydrogenation of alkynes based on in situ generated CuNPs in the presence of hydrogen donors, such as ammonia-borane and a green protic solvent. This environmentally friendly method is characterized by operational simplicity combined with high stereo- and chemoselectivity and functional group compatibility. Auto-oxidation of CuNPs after the completion of a semihydrogenation reaction results in the formation of a water-soluble ammonia complex, so that the catalyst may be reused several times by simple phase-separation with no need for any special regeneration processes. Formed NH4B(OR)4 can be easily transformed back into ammonia-borane or into boric acid. In addition, a one-pot tandem sequence involving a Suzuki reaction followed by semihydrogenation was presented, which allows minimization of chemical waste production.

Design, synthesis, and biological evaluation of linear 1-(4-, 3- or 2-methylsulfonylphenyl)-2-phenylacetylenes: A novel class of cyclooxygenase-2 inhibitors

A group of regioisomeric 1-(methylsulfonylphenyl)-2-phenylacetylenes possessing a COX-2 SO2Me pharmacophore at the para-, meta- or ortho-position of the C-1 phenyl ring, in conjunction with a C-2 phenyl or substituted-phenyl ring substituent (3

BISARYLCYCLOBUTENE DERIVATES AS CYCLOOXYGENASE INHIBITORS

The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).