33667-91-3

Basic information

• Product Name: N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97%
• Synonyms: N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97%
• CAS NO: 33667-91-3
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.2851
• Mol File: 33667-91-3.mol
• Article Data: 36

Chemical Properties

• Melting Point: 71-73 °C(Solv: dichloromethane (75-09-2))
• Boiling Point: 318.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.156±0.06 g/cm3(Predicted)
• PKA: 13.17±0.70(Predicted)
• CAS DataBase Reference: N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97%(33667-91-3)
• EPA Substance Registry System: N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97%(33667-91-3)

Safety Data

• Hazardous Substances Data: 33667-91-3(Hazardous Substances Data)

Upstream product

• 300382-54-1 (4-methoxy-phenyl)-p-tolyl-methanone oxime 
• 5720-07-0 4-methoxyphenylboronic acid 
• 619-55-6 para-methylbenzamide 
• 332-34-3 2,2,2-trifluoro-N-(4-methoxy-phenyl)-acetamide 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 25569-87-3 benzoic-p-methylbenzoic anhydride 
• 104-94-9 4-methoxy-aniline 
• 874-60-2 4-methyl-benzoyl chloride 
• 2101-87-3 p-methoxy-phenylazide 
• 100-17-4 para-methoxynitrobenzene 
• 201230-82-2 carbon monoxide 
• 5720-05-8 4-methylphenylboronic acid 
• 1900-85-2 phenyl p-methylbenzoate 
• 106-42-3 para-xylene 

Downstream Products

• 1254368-96-1 4-(4-methoxyphenyl)-3-(4-nitrophenyl)-5-p-tolyl-4H-[1,2,4]triazole 
• 1254368-95-0 4-[4-(4-methoxyphenyl)-5-p-tolyl-4H-[1,2,4]triazol-3-yl]pyridine 
• 24239-12-1 6-methoxy-2-(4-methylphenyl)-1,3-benzoxazole 
• 84662-52-2 N-(p-anisyl)-4-methylbenzenecarboxyimidoyl chloride 
• 101078-67-5 Acetic acid 2-[4-(diethoxy-phosphorylmethyl)-phenyl]-benzothiazol-6-yl ester 
• 101078-70-0 diethyl 4-(5-hydroxybenzo[d] thiazol-2-yl)benzylphosphonate 
• 101078-57-3 Acetic acid 2-p-tolyl-benzothiazol-6-yl ester 
• 101078-51-7 6-methoxy-2-(4-tolyl)-1,3-benzothiazole 
• 101078-54-0 2-p-Tolyl-benzothiazol-6-ol 
• 681446-06-0 N-[(benzotriazol-1-yl)(4-methylphenyl)methylidene]-4-methoxyaniline 

Relevant articles and documents

Solid-phase synthesis of 3-alkylamino-1,2,4-triazoles

Matrix presented A solid-phase synthesis of trisubstituted 3-alkylamino-1,2,4-triazoles has been developed. The synthesis utilizes immobilized N-acyl-1H-benzotriazole-1-carboximidamides as key intermediates. Cyclization with hydrazines under mild conditio

Amide Bond Formation via the Rearrangement of Nitrile Imines Derived from N-2-Nitrophenyl Hydrazonyl Bromides

We report how the rearrangement of highly reactive nitrile imines derived from N-2-nitrophenyl hydrazonyl bromides can be harnessed for the facile construction of amide bonds. This amidation reaction was found to be widely applicable to the synthesis of primary, secondary, and tertiary amides and was used as the key step in the synthesis of the lipid-lowering agent bezafibrate. The orthogonality and functional group tolerance of this approach was exemplified by the N-acylation of unprotected amino acids.

Palladium(II) Complexes of a Neutral CCC-Tris(N-heterocyclic carbene) Pincer Ligand: Synthesis and Catalytic Applications

Treatment of tris-azolium precursor 1 with palladium acetate under thermal conditions provided a CCC-pincer palladium(II) complex (2) bearing three NHCs (one imidazolylidene and two triazolylidenes) and one iodide ligand. Further treatment of complex 2 with an excess of AgSbF6 generates tris(carbene) dicationic palladium complex 3 in which the iodine ligands are exchanged with SbF6 anions and the metal center is stabilized by one acetonitrile ligand. Complexes 2 and 3 were tested in several cross coupling reactions showing high conversions under low catalyst loadings and mild reaction conditions. Additionally, complexes 2 and 3 performed well in the hydrosilylation of terminal alkynes with good selectivity toward the E-isomer.

Direct amide synthesis: via Ni-mediated aminocarbonylation of arylboronic acids with CO and nitroarenes

Herein we describe an alternative and unconventional approach of an aminocarbonylation reaction to access aryl amides from readily available and low-cost arylboronic acids and nitroarenes. Nickel metal can serve as both reductant and catalyst in this direct aminocarbonylation. This protocol exhibits a good functional group compatibility and allows a variety of aryl amides to be synthesized, including several drug-like molecules.