33745-25-4Relevant articles and documents
Stereoselective tandem Michael-intramolecular cyclization approach to functionalized pyrroloisoindolones
Reyes, Adelfo,Regla, Ignacio,Fragoso, Mabel C.,Vallejo, Laura A.,Demare, Patricia,Jimenez-Vazquez, Hugo A.,Ramirez, Yara,Juaristi, Eusebio,Tamariz, Joaquin
, p. 11187 - 11202 (1999)
A stereoselective synthesis of pyrrolo[2,1-a]isoindol-5-ones is described. The synthesis takes place through a tandem Michael addition- intramolecular cyclization, by the base-promoted condensation of methyl N- phthaloylalaninate with conjugate acceptors at low temperature. The desired products were obtained in good yields as single isomers in only one step. Presumably, the stereoselectivity of the cyclization step is kinetically controlled by a lithium chelate species between the interacting centers. The structure of the adducts is discussed, being supported by NMR experiments and X-ray crystallography.
METHOD FOR ALCOHOLYSIS OF AMIDE
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Paragraph 0041-0042; 0044-0068; 0075-0077; 0129-0135, (2020/03/01)
Provided is a method for the alcoholysis of an amide. The method comprises subjecting an amide-containing compound to alcoholysis under alkaline conditions using an epoxy compound as an accelerant of alcoholysis.
A recyclable CO surrogate in regioselective alkoxycarbonylation of alkenes: Indirect use of carbon dioxide
Gehrtz,Hirschbeck,Fleischer
supporting information, p. 12574 - 12577 (2015/08/06)
Herein, we report a Pd-catalysed alkoxycarbonylation of alkenes based on the use of a recyclable CO2 reduction product, the crystalline and air-stable N-formylsaccharin, as a CO surrogate. The carbonylation proceeds under ambient conditions in an exceptionally complementary regioselective fashion yielding the desired branched products from styrene derivatives and valuable linear esters from alkyl-substituted alkenes.